Recombinant Human PPM1F,GST-tagged

• Cat.No.: PPM1F-1439H
• Product Overview: Recombinant full-length human CaMKPase was expressed inE. colicells using an N-terminal GST tag. MW = 74kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: CaMKPase is a member of the PP2C family of Ser/Thr protein phosphatases that dephosphorylate and regulate the multifunctional Ca2+/calmodulin-dependent protein kinases (CaMKs). The multifunctional CaMKs mediate cellular responses induced by increases in second messenger Ca2+ and have been implicated in the control of synaptic transmission, gene transcription, cell growth and contraction of cardiac and smooth muscles. Overexpression of CaMKPase has been shown to mediate caspase-dependent apoptosis. CaMKPase can also interact with the Rho guanine nucleotide exchange factors (PIX) thereby blocking the effects of p21-activated kinase 1 (PAK1).
• Sequence: Full-length.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PPM1F protein phosphatase 1F (PP2C domain containing) [ Homo sapiens ]
• Synonyms: PPM1F; protein phosphatase 1F (PP2C domain containing); CAMKP; FEM-2; POPX2; hFEM-2; CaMKPase; KIAA0015
• Gene ID: 9647
• mRNA Refseq: NM_014634
• Protein Refseq: NP_055449
• UniProt ID: P49593
• Chromosome Location: 22q11.22
• Function: hydrolase activity; magnesium ion binding; manganese ion binding; protein serine/threonine phosphatase activity