PPM1F
-
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1F -
Overview
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. -
Synonyms
PPM1F;protein phosphatase, Mg2+/Mn2+ dependent, 1F;protein phosphatase 1F (PP2C domain containing);protein phosphatase 1F;Ca(2+)/calmodulin dependent protein kinase phosphatase;CAMKP;CaMKPase;FEM 2;KIAA0015;partner of PIX 2;POPX2;PP2C phosphata
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPM1F-1895H | Recombinant Human PPM1F, His-tagged | E.coli | Human | His | 104-453aa | |
| PPM1F-13199M | Recombinant Mouse PPM1F Protein | Mammalian Cell | Mouse | His |
|
|
| PPM1F-1439H | Recombinant Human PPM1F,GST-tagged | E.coli | Human | GST |
|
|
| PPM1F-2281H | Recombinant Human PPM1F, His-tagged | E.coli | Human | His | 477aa |
|
| PPM1F-2663Z | Recombinant Zebrafish PPM1F | Mammalian Cell | Zebrafish | His |
|
|
| PPM1F-31046TH | Recombinant Human PPM1F | E.coli | Human | Non |
|
|
| PPM1F-2961HCL | Recombinant Human PPM1F 293 Cell Lysate | HEK293 | Human | Non |
|
|
| Ppm1f-5047M | Recombinant Mouse Ppm1f Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
|
| PPM1F-6991M | Recombinant Mouse PPM1F Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| PPM1F-6991M-B | Recombinant Mouse PPM1F Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
PPM1F involved in several pathways and played different roles in them. We selected most pathways PPM1F participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PPM1F has several biochemical functions, for example, calmodulin-dependent protein phosphatase activity,metal ion binding,phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1F itself. We selected most functions PPM1F had, and list some proteins which have the same functions with PPM1F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin-dependent protein phosphatase activity | PPP3CA,PPP3CB,PPM1A |
| phosphatase activity | MTMR7B,MINPP1B,DUSP28,PTPRU,PTPN2A,PTPN22,PPP1CC,DUSP22A,PTPRZ1,CTDNEP1B |
| protein serine/threonine phosphatase activity | PDP2,PPM1DB,TAB1,PP2D1,PTEN,CDC14C,PPP1CC,PPP1R3C,PPEF2,PHLPP2 |
| protein binding | KLF10,MECOM,PTPRZ1,QRICH1,ICA1L,SH3GL3,GLB1,CCNL1,FAM212A,TCTN2 |
| metal ion binding | ZDHHC22,PLEKHM1,MT1X,PCGF5A,ZNF565,PRKRIR,ZNF48,MARCH6,FTR43,PRG4B |
Interacting Protein
PPM1F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPM1F here. Most of them are supplied by our site. Hope this information will be useful for your research of PPM1F.
DIAPH1;FEM1B;CAMK2A;Camkk2;MARS;FAM161A;PRKAA2;PRKAA1;PAK1;PAK2
Resources
Related Services
Related Products
References
