Recombinant Human PPM1B protein, His-tagged

• Cat.No.: PPM1B-79H
• Product Overview: Recombinant Human PPM1B, fused with N-His tag, was expressed in E. coli.

Specification

• Description: Protein phosphatase 1B is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death.
• Source: E.coli
• Species: Human
• Tag: His
• Form: 20mM Tris.Cl, 50mM NaCl, 50% Glycerol, pH8.0.
• Molecular Mass: 54.6kDa(including fusion tag)
• Protein length: 494aa(including fusion tag)
• Applications: WB, ELISA, IP, antibody production, protein array
• Storage: Store at -80centigrade and avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B [ Homo sapiens ]
• Official Symbol: PPM1B
• Synonyms: PPM1B; protein phosphatase, Mg2+/Mn2+ dependent, 1B; protein phosphatase 1B (formerly 2C), magnesium dependent, beta isoform; protein phosphatase 1B; PP2CB; PP2CBETA; PPC2BETAX; protein phosphatase 2C; beta isoform; PP2C-beta; protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; PP2C-beta-X; MGC21657
• Gene ID: 5495
• mRNA Refseq: NM_001033556
• Protein Refseq: NP_001028728
• MIM: 603770
• UniProt ID: O75688
• Chromosome Location: 2p22.1
• Pathway: Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; ISG15 antiviral mechanism, organism-specific biosystem; Immune System, organism-specific biosystem; Interferon Signaling, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem
• Function: hydrolase activity; magnesium ion binding; manganese ion binding; protein binding; protein serine/threonine phosphatase activity; protein serine/threonine phosphatase activity