Recombinant Human POLR2E, His-tagged
| Cat.No. : | POLR2E-28615TH |
| Product Overview : | Recombinant full length human His-tagged POLR2E isolated from an E. coli strain that carries the coding sequence of the protein under the control of a T7 promoter. |
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| Description : | This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. |
| Conjugation : | HIS |
| Source : | E. coli |
| Form : | Liquid |
| Purity : | >95% by SDS-PAGE |
| Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0 |
| Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequence Similarities : | Belongs to the archaeal rpoH/eukaryotic RPB5 RNA polymerase subunit family. |
| Full Length : | Full L. |
| Gene Name | POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa [ Homo sapiens ] |
| Official Symbol | POLR2E |
| Synonyms | POLR2E; polymerase (RNA) II (DNA directed) polypeptide E, 25kDa; polymerase (RNA) II (DNA directed) polypeptide E (25kD); DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA directed RNA polymerase II 23 kda polypeptide; hRPB25; hsRPB5; RPABC1 |
| Gene ID | 5434 |
| mRNA Refseq | NM_002695 |
| Protein Refseq | NP_002686 |
| MIM | 180664 |
| Uniprot ID | P19388 |
| Chromosome Location | 19p13.3 |
| Pathway | Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; DNA Repair, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem; |
| Function | DNA binding; DNA-directed RNA polymerase activity; contributes_to protein kinase activity; |
Not For Human Consumption!
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