Recombinant Human PLA2G2A Protein (Asn21-Cys144), His tagged

• Cat.No.: PLA2G2A-4923H
• Product Overview: Recombinant human PLA2G2A (Asn21-Cys144) fused with His tag was expressed in E. coli.

Specification

• Description: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 15.96 kDa
• Protein length: Asn21-Cys144
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) [ Homo sapiens (human) ]
• Official Symbol: PLA2G2A
• Synonyms: PLA2G2A; phospholipase A2, group IIA (platelets, synovial fluid); PLA2B, PLA2L; phospholipase A2, membrane associated; NPS-PLA2; GIIC sPLA2; group IIA phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A; non-pancreatic secretory phospholipase A2; MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2
• Gene ID: 5320
• mRNA Refseq: NM_000300
• Protein Refseq: NP_000291
• MIM: 172411
• UniProt ID: P14555

Reviews

11/23/2022

PLA2G2A's ability to easily attach to the surface of a cell or material.

06/14/2022

It has the characteristics of high safety in clinical treatment.

04/30/2022

The operation is very simple, get started quickly, easy to use, will recommend to others.

Q&As

How to use the expression pattern of PLA2G2A protein for disease diagnosis?

By detecting the expression pattern of PLA2G2A proteins, it can assist in the diagnosis of certain diseases, such as inflammatory diseases, cardiovascular diseases, cancer, etc.

What is the role of PLA2G2A proteins in the immune system?

PLA2G2A proteins have the role of regulating inflammatory response and apoptosis in the immune system, which can affect the survival and function of immune cells.

How to study the regulatory mechanisms of PLA2G2A proteins?

Studying the regulatory mechanism of PLA2G2A proteins requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

Is the expression of PLA2G2A protein related to the stage of disease development?

The expression of PLA2G2A protein may be related to the stage of the disease, and the expression level of the PLA2G2A protein may change at different stages of the disease development.

What are the types of mutations in PLA2G2A proteins?

The types of mutations in PLA2G2A proteins include point mutations, insertions/deletions, duplications, etc., which can lead to structural and functional abnormalities of the protein.

What is the relationship of PLA2G2A protein to other genes or proteins?

PLA2G2A proteins have complex relationships with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.