Recombinant Human PIM3 Protein (1-309), His tagged

• Cat.No.: PIM3-4507H
• Product Overview: Recombinant human PIM3 (1-309) fused with His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-309
• Description: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X (L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 35.05 kDa
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: PIM3 pim-3 oncogene [ Homo sapiens (human) ]
• Official Symbol: PIM3
• Synonyms: PIM3; pim-3 oncogene; serine/threonine-protein kinase pim-3; serine/threonine kinase Pim-3; pim-3
• Gene ID: 415116
• mRNA Refseq: NM_001001852
• Protein Refseq: NP_001001852
• MIM: 610580
• UniProt ID: Q86V86