Recombinant Human PIAS4 Protein, MYC/DDK-tagged, C13 and N15-labeled
Cat.No. : | PIAS4-246H |
Product Overview : | PIAS4 MS Standard C13 and N15-labeled recombinant protein (NP_056981) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Species : | Human |
Source : | HEK293 |
Tag : | DDK&Myc |
Description : | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. |
Molecular Mass : | 56.5 kDa |
AA Sequence : | MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKELYETRYAKKNSEPAPQPHRPLDPLTMHSTYDRAGAVPRTPLAGPNIDYPVLYGKYLNGLGRLPAKTLKPEVRLVKLPFFNMLDELLKPTELVPQNNEKLQESPCIFALTPRQVELIRNSRELQPGVKAVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPCRPINLTHLMYLSSATNRITVTWGNYGKSYSVALYLVRQLTSSELLQRLKTIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAPYDQLIIDGLLSKILSECEDADEIEYLVDGSWCPIRAEKERSCSPQGAILVLGPSDANGLLPAPSVNGSGALGSTGGGGPVGSMENGKPGADVVDLTLDSSSSSEDEEEEEEEEEDEDEEGPRPKRRCPFQKGLVPACTRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name | PIAS4 protein inhibitor of activated STAT, 4 [ Homo sapiens (human) ] |
Official Symbol | PIAS4 |
Synonyms | PIAS4; protein inhibitor of activated STAT, 4; E3 SUMO-protein ligase PIAS4; FLJ12419; Piasg; PIASY; zinc finger; MIZ type containing 6; ZMIZ6; PIAS-gamma; zinc finger, MIZ-type containing 6; protein inhibitor of activated STAT protein 4; protein inhibitor of activated STAT protein PIASy; protein inhibitor of activated STAT protein gamma; MGC35296; |
Gene ID | 51588 |
mRNA Refseq | NM_015897 |
Protein Refseq | NP_056981 |
MIM | 605989 |
UniProt ID | Q8N2W9 |
◆ Recombinant Proteins | ||
PIAS4-1674H | Recombinant Human PIAS4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Pias4-4850M | Recombinant Mouse Pias4 Protein, Myc/DDK-tagged | +Inquiry |
Pias4-1939M | Recombinant Mouse Pias4 Protein, His-tagged | +Inquiry |
PIAS4-1442HFL | Recombinant Full Length Human PIAS4 Protein, C-Flag-tagged | +Inquiry |
PIAS4-246H | Recombinant Human PIAS4 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
◆ Cell & Tissue Lysates | ||
PIAS4-3201HCL | Recombinant Human PIAS4 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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