Recombinant Human Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide, His-tagged

• Cat.No.: PIK3CD-1896H
• Product Overview: Recombinant HumanPIK3CD (p110-delta/p85-alpha) were co-expressed using an N-terminal His Tagon both proteins.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Description: PIK3CD(p110-delta/p85-alpha) Active is a member of the PI3K family thatphosphorylates phosphoinositides on the 3-hydroxyl group of the inositolring. PIK3CD plays a role in oncogenic transformation, and is consistetlyexpressed at a high level in blast cells. PIK3CD can play a selective role inthe amplification of phosphatidylinositol triphosphate (PIP3) levels thatlead to neutrophil polarization, and regulates directional migration, but notrandom locomotion. PI3K signaling pathway is involved in immune responsesrelevant to the pathogenesis of rheumatoid arthritis and other inflammatorydiseases.
• Form: Frozen liquid in 50mM Sodium Phosphate pH 7.0 + 300 mM NaCl + 150 mM Imidazole + 0.1 mM PMSF +0.25 mM DTT + 25% Glycerol.
• Molecular Weight: p110-delta~111 kDa,p85-alpha~86 kDa
• Purity: > 80% bydensitometry
• Specific Activity: 50 nmol/min/mg
• Storage: Store at -70°C. 1year. For optimal storage, aliquot into smaller quantities. Avoid repeated freeze-thawcycles.
• OfficialSymbol: PIK3CD

Gene Information

• Gene Name: PIK3CD phosphoinositide-3-kinase,catalytic, delta polypeptide [ Homo sapiens ]
• Synonyms: PIK3CD;phosphoinositide-3-kinase, catalytic, delta polypeptide; PI3K; p110D;P110DELTA; catalytic phosphatidylinositol 3-kinase delta;phosphoinositide-3-kinase C; PI3-kinase p110 subunit delta;phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; EC2.7.1.153; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunitdelta isoform; PtdIns-3-kinase p110; p110delta; PI3K-delta; PI3K delta;PtdIns-3-kinase subunit delta; Phosphatidylinositol-4,5-bisphosphate 3-kinase110 kDa catalytic subunit delta; PtdIns-3-kinase subunit p110-delta
• Gene ID: 5293
• mRNA Refseq: NM_005026
• Protein Refseq: NP_005017
• MIM: 602839
• UniProt ID: O00329
• Chromosome Location: 1p36.2
• Pathway: 3-phosphoinositidebiosynthesis; Acutemyeloid leukemia; Apoptosis; B cell receptor signaling pathway; Chemokinesignaling pathway; Chronic myeloid leukemia; Colorectal cancer; Endometrialcancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Focaladhesion; Glioma; Inositol phosphate metabolism; Insulin signaling pathway;Jak-STAT signaling pathway; Leukocyte transendothelial migration
• Function: 1-phosphatidylinositol-3-kinaseactivity; ATP binding; binding; kinase activity; nucleotide binding;phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphotransferaseactivity, alcohol group as acceptor; transferase activity