PIK3CD

  • Official Full Name

    phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

  • Overview

    Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]

  • Synonyms

    PIK3CD;phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta;APDS;PI3K;IMD14;p110D;P110DELTA;phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform;PI3Kdelta;phosphoinositide-3-kinase C;PI3-kinase p110 subunit delta;ptdIns-3-kinase subunit p110-delta;phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta;phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta;phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Sf21 Cells
  • Mammalian Cells
  • Sf9 Cells
  • HEK293
  • E.coli
  • Flag
  • GST
  • His
  • Non
  • His&T7
Cat.# Product name Source (Host) Species Tag Protein Length Price
PIK3CD-1687HF Active Recombinant Full Length Human PIK3CD Protein, DDK-tagged, Biotinylated Sf21 Cells Human Flag Full L. 1-1044(end)
PIK3CD-8212HF Active Recombinant Full Length Human PIK3CD Protein, GST-tagged Sf21 Cells Human GST Full L. 1-1044(end)
PIK3CD-11416Z Recombinant Zebrafish PIK3CD Mammalian Cells Zebrafish His
PIK3CD-1896H Recombinant Human Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide, His-tagged Sf9 Cells Human His
PIK3CD-1989C Recombinant Chicken PIK3CD Mammalian Cells Chicken His
PIK3CD-29587TH Recombinant Human PIK3CD Human Non Full L.
PIK3CD-52H Recombinant Human PIK3CD, GST-tagged Sf9 Cells Human GST
PIK3CD-3187HCL Recombinant Human PIK3CD 293 Cell Lysate HEK293 Human Non
PIK3CD-1727H Recombinant Human PIK3CD protein, His & T7-tagged E.coli Human His&T7 Val774~Gln1044
PIK3CD-301404H Recombinant Human PIK3CD protein, GST-tagged E.coli Human GST Tyr395-Leu580
PIK3CD-4900H Recombinant Human PIK3CD Protein (Val774-Gln1044), N-His tagged E.coli Human His Val774-Gln1044

    Involved Pathway

    PIK3CD involved in several pathways and played different roles in them. We selected most pathways PIK3CD participated on our site, such as Inositol phosphate metabolism,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of lipolysis in adipocytes PRKACA,PIK3R1,AKT1,GNAI1,PIK3CB,INSR,PIK3CG,Adcy4,PRKACB,NPR1
    Apoptosis IKBKG,GZME,PIK3CA,HIST1H1C,PRKAR2AA,MYD88,PRKAR2AB,CASP8,CDK5RAP2,PRKAR1B
    Acute myeloid leukemia FLT3,MTOR,ARAF,RELA,ZBTB16,PIK3R1,PIK3CG,RARA,JUP,STAT5A
    Amoebiasis LAMB1,LAMA5,COL1A1,COL27A1,NFKB1,COL2A1,C8G,C9,ARG1,COL4A1
    Prolactin signaling pathway MAPK3,LHB,SHC2,CCND1,SRC,INS1,NFKB1,INS2,SOCS1,CCND2
    B Cell Receptor Signaling Pathway CARD11,BANK1,DUSP4,ARPC1B,CRK,GSK3B,RASGRP3,SLA2,BTK, Cd79b
    Small cell lung cancer ITGA6,LAMA3,ITGAV,RARB,LAMA4,IKBKB,PIK3CG,TRAF5,ITGA3,PTEN
    Estrogen signaling pathway PLCB1,PIK3CG,MAP2K1,GNAI1,OPRM1,HSP90AA1,PLCB4,CREB3L3,HSPA8,CALM4
    Non-small cell lung cancer GRB2,PDPK1,FOXO3,EML4,KRAS,AKT1,PRKCA,ALK,RB1,RXRB

    Protein Function

    PIK3CD has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity,1-phosphatidylinositol-4-phosphate 3-kinase activity,ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CD itself. We selected most functions PIK3CD had, and list some proteins which have the same functions with PIK3CD. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding IRAK1,ACTA1A,MADD,Adcy4,ORC1L,PANK1,HSPH1,CHD2,ABCA7,DHX15
    phosphatidylinositol 3-kinase activity PIK3CB,PIK3CG,PIK3C2A,PIK3CA
    protein binding ORC3L,TMEM19,RAB10,SPINK7,SNCA,WHSC1L1,SOX15,SHMT2,TSPAN4,C6
    1-phosphatidylinositol-4-phosphate 3-kinase activity PIK3CA,PIK3C2B,PIK3C2G,PIK3CG,PIK3C2A,PIK3CB
    1-phosphatidylinositol-3-kinase activity PIK3R3,PIK3CA,PIK3CG,PIK3CB,PIK3C3,PIK3C2B,ATM,PIK3C2G,PIK3C2A
    phosphatidylinositol-4,5-bisphosphate 3-kinase activity PIK3CB,PIK3CG,PIK3CA

    Interacting Protein

    PIK3CD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CD here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CD.

    PIK3R1;1-phosphatidyl-1d-myo-inositol;pi3kr1_cerae_protein;HRAS;CD37;NCK1;TNPO2;FAM195A;ASCC2;RALY

    PIK3CD Related Signal Pathway

    Resources

    Gene Families

    TGF-β Superfamily Signaling

    Research Area

    Cancer Drug Targets
    Apoptosis Intracellular Kinases
    Diabetic Peripheral Neuropathy
    PI 3-Kinases (Phosphoinositide 3-Kinases)
    Intracellular Signaling Molecules in Angiogenesis
    Apical-basal Polarity Effectors
    T Follicular Helper (Tfh) Cells
    PI3K Pathway

    References

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