Recombinant Human Phosphodiesterase 7A, GST-tagged, Active

• Cat.No.: PDE7A-481H
• Product Overview: Recombinant human PDE7A (104-end) was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 64 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 104-end a.a.
• Description: PDE7A is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and cGMP. PDE7A is a high-affinity cAMP-specific PDE and is expressed in T cell lines, peripheral blood T lymphocytes, epithelial cell lines, airway and vascular smooth muscle cells, lung fibroblasts, and eosinophils. PDE7 plays a critical role in the regulation of human T cell function and selective PDE7 inhibitors are being examined to treat immunological and inflammatory disorders. PDE7A plays an important role in the regulation of osteoblastic differentiation. PDE7A depletion by RNAi upregulates expression of several osteogenic genes and increases mineralization.
• Sequence: 104-end.
• Applications: PDE Assay.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PDE7A phosphodiesterase 7A [ Homo sapiens ]
• Synonyms: PDE7A; phosphodiesterase 7A; HCP1; PDE7; phosphodiesterase isozyme 7; EC 3.1.4.17; High affinity cAMP-specific 3",5"-cyclic phosphodiesterase 7A; TM22
• Gene ID: 5150
• mRNA Refseq: NM_002603
• Protein Refseq: NP_002594
• MIM: 171885
• UniProt ID: Q13946
• Chromosome Location: 8q13
• Pathway: Progesterone-mediated oocyte maturation; Purine metabolism
• Function: 3",5"-cyclic-AMP phosphodiesterase activity; hydrolase activity