Recombinant Human PHB
Cat.No. : | PHB-29709TH |
Product Overview : | Recombinant full length Human Prohibitin with an N terminal proprietary tag; Predicted MWt 55.66 kDa inclusive of tag. |
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Species : | Human |
Source : | Wheat Germ |
Tag : | Non |
Protein Length : | 272 amino acids |
Description : | Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed.It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor.Mutations in PHB have been linked to sporadic breast cancer.Prohibitin is expressed as two transcripts with varying lengths of 3 untranslated region.The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3 untranslated region may function as a trans-acting regulatory RNA. |
Molecular Weight : | 55.660kDa inclusive of tags |
Tissue specificity : | Widely expressed in different tissues. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVVFD RFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVIT GSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLP SITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAAT FGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVV EKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRK LEAAGDIAYQLSRSRNITYLPAGQSVLLQLPQ |
Sequence Similarities : | Belongs to the prohibitin family. |
Gene Name | PHB prohibitin [ Homo sapiens ] |
Official Symbol | PHB |
Synonyms | PHB; prohibitin; PHB1; |
Gene ID | 5245 |
mRNA Refseq | NM_002634 |
Protein Refseq | NP_002625 |
MIM | 176705 |
Uniprot ID | P35232 |
Chromosome Location | 17q21 |
Function | histone deacetylase binding; protein binding; transcription regulatory region DNA binding; |
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◆ Cell & Tissue Lysates | ||
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Not For Human Consumption!
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