Recombinant Human Peroxiredoxin 3, T7-tagged

• Cat.No.: PRDX3-822H
• Product Overview: Recombinant PRDX3 protein, fused to T7-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques, 27693Da (256aa).

Specification

• Cat. No.: PRDX3-822H
• Description: Thioredoxin-dependent peroxide reductase, mitochondrial is anenzymethat in humans is encoded by the PRDX3gene. This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.
• Sequences of amino acids: MAAAVGRLLR ASVARHVSAI PWGISATAAL RPAACGRTSL TNLLCSGSSQ AKLFSTSSSC HAPAVTQHAP YFKGTAVVNG EFKDLSLDDF KGKYLVLFFY PLDFTFVCPT EIVAFSDKAN EFHDVNCEVV AVSVDSHFSH LAWINTPRKN GGLGHMNIAL LSDLTKQISR DYGVLLEGSG LALRGLFIID PNGVIKHLSV NDLPVGRSVE ETLRLVKAFQ YVETHGEVCP ANWTPDSPTT KPSPAASKEY FQKVNQ
• Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT
• Purity: 95% by SDS - PAGE
• Applications: MS. SDS

Gene Information

• Gene Name: PRDX3 peroxiredoxin 3 [Homo sapiens]
• Synonyms: PRDX3; MER5; AOP-1; AOP1; MGC104387; MGC24293; PRO1748; SP-22; HBC 189; peroxiredoxin 3; Antioxidant protein 1; peroxiredoxin-3; thioredoxin-dependent peroxide redutase, mitochondrial; prx-III; SP-22; Peroxiredoxin III; EC 1.11.1.15; Protein MER5 homolog; Prx-III; Peroxiredoxin-3
• Gene ID: 10935
• mRNA Refseq: NM_006793
• Protein Refseq: NP_006784
• MIM: 604769
• UniProt ID: P30048
• Chromosome Location: 10q25-q26
• Function: Alkyl hydroperoxide reductase activity; caspase inhibitor activity; identical protein binding; kinase binding; oxidoreductase activity; peroxidase activity; peroxiredoxin activity; protein C-terminus binding; protein binding; protein kinase binding