PRDX3
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Official Full Name
Peroxiredoxin 3 -
Overview
This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
PRDX3;peroxiredoxin 3;AOP1;MER5;AOP-1;SP-22;PRO1748;MGC24293;MGC104387;thioredoxin-dependent peroxide reductase, mitochondrial;HBC189;prx-III;peroxiredoxin-3;peroxiredoxin III;OTTHUMP00000020590;protein MER5 homolog;antioxidant protein 1;EC 1.11.1.15
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- E. coli
- HEK293T
- Non
- His
- His&GST
- T7
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PRDX3 involved in several pathways and played different roles in them. We selected most pathways PRDX3 participated on our site, such as Cellular responses to stress,Detoxification of Reactive Oxygen Species,Selenium Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Selenium Pathway | SELT,SAA4,DIO2,SAA2-SAA4,SAA2,MSRB1,SELK,TXNRD2,SERPINA3,TXNRD3IT1 |
| Validated targets of C-MYC transcriptional activation | PEG10,PDCD10,HUWE1,SERPINI1,CDCA7,MINA,MTDH,MYCT1,DDX18,LIN28B |
| Detoxification of Reactive Oxygen Species | TXNRD2,TXN2,Txn1,PRDX2,TXN |
| Cellular responses to stress | EEF1A1,ATG9A,AMBRA1,DNAJC2,PRDX2,GABARAPL2,EPAS1B,RBBP4,KDM6B,HIST1H1D |
Protein Function
PRDX3 has several biochemical functions, for example, alkyl hydroperoxide reductase activity,cysteine-type endopeptidase inhibitor activity involved in apoptotic process,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDX3 itself. We selected most functions PRDX3 had, and list some proteins which have the same functions with PRDX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SYCP1,TOB1A,FAM115A,KIR2DL4,ERBB4,ZGPAT,CCDC68,ZNF238,AUNIP,GNPDA1 |
| kinase binding | LDHB,SNAI1,MIDN,ATF5,WWC2,HSP90AB1,JAKMIP2,WWC3,FAS,STX1A |
| thioredoxin peroxidase activity | PRDX4,PRDX1,PRDX2 |
| alkyl hydroperoxide reductase activity | RYROXD1 |
| protein C-terminus binding | LIG4,CDK7,ATF4,PIAS4,PRKAA1,VPS36,VPS4A,YWHAQ,HAND2,ERCC1 |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | DPEP1,C1QL4L,TNFAIP8,SNCA,SERPINB1A,GAS6,NOL3,RPS6KA1,BIRC3,BIRC5 |
| protein kinase binding | WAS,MAP3K1,TRAF6,ATG13,E2F1,CDKN2A,PARK2,AKAP7,MAPK4,MAP2K3 |
| identical protein binding | DPY30,FAS,MTSS1,AXIN1,RUVBL2,TTC32,APLP1,VAMP2,TOPBP1,IK |
Interacting Protein
PRDX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDX3.
LRRK2;GORASP2;VCAM1
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