Recombinant Human PEBP1

• Cat.No.: PEBP1-29533TH
• Product Overview: Recombinant human PEBP1 was expressed in E. coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: Phosphatidylethanolamine binding protein 1 (PEBP1) is a member of the phosphatidylethanolamine-binding protein family and a serine protease inhibitor which inhibits thrombin, neuropsin. PEBP1 plays a pivotal modulatory role in several protein kinase signaling cascades. Protein kinase C (PKC) phosphorylates PEBP1, resulting in release of Raf-1 and activation of MEK and ERK. Expressed in many tissues, PEBP1 is implicated in the regulation of such physiological processes as membrane biosynthesis, spermatogenesis, neural development, and metastasis suppression.
• Molecular Mass: 21 kDa (187aa), confirmed by MALDI-TOF.
• Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol
• Purity: > 95% by SDS - PAGE
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method )
• Applications: SDS-PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4oC short term (1-2 weeks). For long term storage, aliquot and store at -20oC or -70oC. Avoid repeated freezing and thawing cycles.
• OfficialSymbol: PEBP1

Gene Information

• Gene Name: PEBP1 phosphatidylethanolamine binding protein 1 [ Homo sapiens ]
• Synonyms: PEBP1; phosphatidylethanolamine binding protein 1; PBP, prostatic binding protein; phosphatidylethanolamine-binding protein 1; HCNP; hippocampal cholinergic neurostimulating peptide; PEBP; Raf kinase inhibitory protein; RKIP
• Gene ID: 5037
• mRNA Refseq: NM_002567
• Protein Refseq: NP_002558
• MIM: 604591
• UniProt ID: P30086
• Chromosome Location: 12q24.23
• Pathway: Aurora B signaling; EGFR1 Signaling Pathway; ErbB1 downstream signaling; TNF-alpha/NF-kB Signaling Pathway
• Function: ATP binding; mitogen-activated protein kinase binding; phosphatidylethanolamine binding; receptor binding; serine-type endopeptidase inhibitor activity