PEBP1
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Official Full Name
phosphatidylethanolamine binding protein 1 -
Overview
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase.HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor. -
Synonyms
PEBP1;phosphatidylethanolamine binding protein 1;PBP, prostatic binding protein;phosphatidylethanolamine-binding protein 1;HCNP;hippocampal cholinergic neurostimulating peptide;PEBP;Raf kinase inhibitory protein;RKIP;neuropolypeptide h3;prostat
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Chicken
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- E. coli
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PEBP1 involved in several pathways and played different roles in them. We selected most pathways PEBP1 participated on our site, such as ARMS-mediated activation,Aurora B signaling,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PEBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DAP12 signaling | FRS2,JAK1,FRS2A,PEA15A,DUSP9,TRAT1,IL17RD,RASGEF1A,AGO3,SPTBN1 |
| Developmental Biology | DUSP10,SEMA3AA,ADAM22,NR2F2,CD24,DAB2IPB,MED22,ARPC5,NADL1.1,TDGF1 |
| Axon guidance | TRPC5,CSF2,CLTC,GFRA2,FYN,PLXNA1,NFATC2,KALRN,CXCR4,ROBO2 |
| ARMS-mediated activation | DUSP9,NRG2A,PSMA8,DUSP1,FGF8B,CSF2RB,PSMD14,WDR83,SPNA2,PHB |
| Aurora B signaling | KIF2C,NDC80,SEPT1,INCENP,RACGAP1,DES,TACC1,KIF20A,SMC4,CBX5 |
| Cytokine Signaling in Immune system | SPNA1,DUSP2,TRIM6,PEA15,SPNA2,BST2,ARIH1,SPRED1,CRK,IFIT8 |
| Downstream signal transduction | SPNA1,FRS2A,PEA15,AGO2,FGFR1B,DUSP9,TRAT1,CRKL,SPTBN2,SPRED1 |
| DAP12 interactions | FGF20A,SIGLEC14,DUSP2,TREM1,FGF18B,SPTBN2,IL17RD,DUSP1,TRAT1,JAK1 |
Protein Function
PEBP1 has several biochemical functions, for example, ATP binding,enzyme binding,phosphatidylethanolamine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEBP1 itself. We selected most functions PEBP1 had, and list some proteins which have the same functions with PEBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | WIBG,HNRNPC,RPS11,SLC25A5,GLRX3,EEF1A1,PDIA4,LRPPRC,RPS27.1,ERI3 |
| serine-type endopeptidase inhibitor activity | SPINK8,SPINK6,SERPINA12,SPINT1A,SERPINA1L,ITIH6,PAPLN,SERPINI2,SERPINA5,KAL1 |
| ATP binding | PFKFB2A,ROCK2,AK7,NUAK1,FYN,NLRP4C,OXSR1,CASK,VWA8,PSTK |
| protein binding | TLE1,MORF4L2,S100P,NKX2-5,INTS5,DTX3L,DPM2,PALM,ITGB1,PNMA2 |
| enzyme binding | ABCD1,MDM2,UBE2I,UGT1A6,HIST1H2AG,TSPAN14,HIST1H2AK,EIF2AK3,PPP3CA,BCR |
| protein kinase binding | PTPN6,CD3E,NGFRAP1,B4GALT1,CDC25B,TICAM1,DNAJA3,FZD5,EEF2,RPTOR |
| phosphatidylethanolamine binding | LC3,PEMT,CD300A,ESYT2,NF1,MFGE8,ANXA11 |
Interacting Protein
PEBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEBP1.
RAF1;EPB41;CDK2;PIK3R1;HLA-B;VHL;PAK2;PINX1;TMBIM4;SMYD2;FTSJ1;PACSIN3;TRAF6;STC2
Resources
Research Area
Serine Proteases and RegulatorsPhospholipases, Small GTPases, and Other Molecules in the Akt Pathway
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References
