Recombinant Human PDZK1

• Cat.No.: PDZK1-30832TH
• Product Overview: Recombinant full length Human PDZK1 with N terminal proprietary tag; Predicted MWt 83.2 kDa.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 519 amino acids
• Description: This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Molecular Weight: 83.200kDa inclusive of tags
• Tissue specificity: Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carci
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MTSTFNPRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEK CSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRKSGN SVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILS PVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYM TDITPQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKV KKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQ PRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEA GLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVV DKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSL EVSSPPDTTEEVDHKPKLCRLAKGENGYGFHLNAIRGLPG SFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVV DRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDT PPDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDTEM
• Sequence Similarities: Belongs to the NHER family.Contains 4 PDZ (DHR) domains.

Gene Information

• Gene Name: PDZK1 PDZ domain containing 1 [ Homo sapiens ]
• Official Symbol: PDZK1
• Synonyms: PDZK1; PDZ domain containing 1; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; NHERF3; PDZD1
• Gene ID: 5174
• mRNA Refseq: NM_001201325
• Protein Refseq: NP_001188254
• MIM: 603831
• Uniprot ID: Q5T2W1
• Chromosome Location: 1q21
• Function: PDZ domain binding; protein binding; scavenger receptor binding; transporter activity