Recombinant Human PDK3, His-tagged

• Cat.No.: PDK3-652H
• Product Overview: Recombinant Human PDK3 with a His tag is expressed inBacteriaand column-purified.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: PDH kinases (PDK"s) deactivate PDH by reversible phosphorylation. In humans and rodents, 4 PDK"s are present in an organ-dependent manner. In all cases, PDK"s are physically part of the PDH complex (binding via lipoyl domain 2 of E2), and they phosphorylate the E1 subunit at 3 specific serine residues. PDH phosphatases remove the phosphorylation and restore activity of PDH.
• Storage: Store at -80°C.

Gene Information

• Gene Name: PDK3 pyruvate dehydrogenase kinase, isozyme 3 [ Homo sapiens ]
• Synonyms: PDK3; pyruvate dehydrogenase kinase, isozyme 3; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 3; pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial; EC 2.7.11.2
• Gene ID: 5165
• mRNA Refseq: NM_001142386
• Protein Refseq: NP_001135858
• MIM: 602526
• UniProt ID: Q15120
• Chromosome Location: Xp22.11
• Pathway: Integration of energy metabolism; Pyruvate metabolism and Citric Acid (TCA) cycle
• Function: ATP binding; nucleotide binding; protein heterodimerization activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; protein homodimerization activity; transferase activity; two-component sensor activity