Recombinant Human PDE7B

• Cat.No.: PDE7B-30224TH
• Product Overview: Recombinant fragment corresponding to amino acids 107-450 of Human PDE7B with N terminal proprietary tag, expressed in a Baculovirus infected Sf9 cell expression system, 66 kDa

Specification

• Description: The 3,5-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3,5-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.
• Biological activity: Specific Activity: 53 pmol/min/μg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Tag: Non
• Protein length: 107-450 a.a.

Gene Information

• Gene Name: PDE7B phosphodiesterase 7B [ Homo sapiens ]
• Official Symbol: PDE7B
• Synonyms: PDE7B; phosphodiesterase 7B; cAMP-specific 3,5-cyclic phosphodiesterase 7B
• Gene ID: 27115
• mRNA Refseq: NM_018945
• Protein Refseq: NP_061818
• MIM: 604645
• Uniprot ID: Q9NP56
• Chromosome Location: 6q23-q24
• Pathway: G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem
• Function: 3,5-cyclic-AMP phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity