Recombinant Human PDE4C, GST-tagged, Active

• Cat.No.: PDE4C-477H
• Product Overview: Recombinanthuman PDE4C (287-end) was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=75kDa.

Specification

• Cat. No.: PDE4C-477H
• Description: PDE4C is a member of the phosphodiesterase (PDE) family that is cAMP-specific and has homology to the "dunce" gene of Drosophila. The "dunce" gene is one of several genes critical for normal learning and memory in the fly. Homozygous mutations in "dunce" cause defective short-term memory and behavioral defects. PDE4C is assigned to human chromosome 19 by Southern analyses while in situ hybridization localized the PDE4C gene to 19p13.1.
• Source: Sf9 insect cells using baculovirus.
• Sequence: 287-end.
• Applications: PDE Assay.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• 22q13.33: 19p13.11
• Protein length: 287-end a.a.

Gene Information

• Gene Name: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) [ Homo sapiens ]
• Synonyms: PDE4C; phosphodiesterase 4C, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); DPDE1; MGC126222; phosphodiesterase 4C; EC 3.1.4.17
• Gene ID: 5143
• mRNA Refseq: NM_000923
• Protein Refseq: NP_000914
• MIM: 600128
• UniProt ID: Q08493
• Pathway: Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR
• Function: 3",5"-cyclic-AMP phosphodiesterase activity; hydrolase activity