PDE4C
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Official Full Name
phosphodiesterase 4C, cAMP-specific -
Overview
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
PDE4C;phosphodiesterase 4C, cAMP-specific;DPDE1, phosphodiesterase 4C, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E1);cAMP-specific 3,5-cyclic phosphodiesterase 4C;phosphodiesterase E1 dunce homolog (Drosophila);cAMP specific 3 5 cyclic phosphodiesterase 4C;DPDE 1;DPDE1;MGC126222;PDE 21;PDE 4C;PDE21;Phosphodiesterase 4C;Phosphodiesterase 4C cAMP specific;Phosphodiesterase E1 dunce homolog;Phosphodiesterase E1 dunce homolog Drosophila;Phosphodiesterase Type 4C;phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
Recombinant Proteins
- Human
- Mouse
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PDE4C-1600H | Recombinant Human PDE4C, GST-tagged | E.coli | Human | GST | 259-322aa | |
| PDE4C-2481H | Recombinant Human PDE4C protein, His-tagged | E.coli | Human | His | 28-91 aa | |
| PDE4C-1528H |
Active Recombinant Human PDE4C, GST-tagged
|
Sf9 Insect Cell | Human | GST | 287 aa-end |
|
| PDE4C-12555M | Recombinant Mouse PDE4C Protein | Mammalian Cell | Mouse | His |
|
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| PDE4C-30820TH | Recombinant Human PDE4C | Human | Non | Full L. |
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| PDE4C-477H | Recombinant Human PDE4C, GST-tagged, Active | Sf9 Insect Cell | Human | GST | 287-end a.a. |
|
| PDE4C-3351HCL | Recombinant Human PDE4C 293 Cell Lysate | HEK293 | Human | Non |
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| Kit-1840 | PDE4C Assay Kit | Non |
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| Pde4c-470M | Recombinant Mouse Pde4c Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| PDE4C-6585M | Recombinant Mouse PDE4C Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PDE4C-6585M-B | Recombinant Mouse PDE4C Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PDE4C involved in several pathways and played different roles in them. We selected most pathways PDE4C participated on our site, such as Purine metabolism,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | CAMK4,GPR81,GHSR,PRKACA,NFKB1,ATP2A2,PLD1,ATP1B3,RAC3,MAPK3 |
| Purine metabolism | POLE2,NTPCR,POLD1,CANT1A,ENTPD1,NME2,POLR3C,PNP6,AMPD1,NT5E |
Protein Function
PDE4C has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity,drug binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4C itself. We selected most functions PDE4C had, and list some proteins which have the same functions with PDE4C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PPIH,ZFP335,CEP44,PSMB10,ERCC2,SEC16B,NIP7,SYK,MRAP,NAE1 |
| drug binding | HTR1B,CHRNB4,PPARD,DRD2,FNTB,FSCN1,SRP54A,CHRNB2,PYGM,TYMS |
| 3,5-cyclic-AMP phosphodiesterase activity | PDE8B,PDE7A,PDE7B,PDE1B,PDE4D,PDE4A,PDE3A,USB1,TDP2B,PDE4B |
| metal ion binding | ACSM4,ZFPM1,ZFP771,ZFAT,LFNG,TRIM50,ROR2,TRIM71,PM20D1.2,RNF145B |
Interacting Protein
PDE4C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4C here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4C.
Resources
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References
- Surmiak, M; Kaczor, M; et al. EXPRESSION PROFILE OF PROINFLAMMATORY GENES IN NEUTROPHIL-ENRICHED GRANULOCYTES STIMULATED WITH NATIVE ANTI-PR3 AUTOANTIBODIES. JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 63:249-256(2012).
- Curatola, AM; Xu, J; et al. Cyclic GMP protects endothelial progenitors from oxidative stress. ANGIOGENESIS 14:267-279(2011).
