Recombinant Human PCDHGA8 Protein, His-tagged

• Cat.No.: PCDHGA8-2561H
• Product Overview: Recombinant Human PCDHGA8 Protein (Gln30-Glu253) with a N-His tag was expressed in E. coli.

Specification

• Description: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 28.4 kDa
  Accurate Molecular Mass: 28 kDa
• Protein length: Gln30-Glu253
• Endotoxin: <1.0 EU per 1µg (determined by the LAL method).
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: PCDHGA8 protocadherin gamma subfamily A, 8 [ Homo sapiens (human) ]
• Official Symbol: PCDHGA8
• Synonyms: PCDHGA8; protocadherin gamma subfamily A, 8; protocadherin gamma-A8; KIAA0327; PCDH GAMMA A8; PCDH-GAMMA-A8
• Gene ID: 9708
• mRNA Refseq: NM_014004
• Protein Refseq: NP_054723
• MIM: 606295
• UniProt ID: Q9Y5G5