Recombinant Human PAX3 Protein, C-His tagged

• Cat.No.: PAX3-58H
• Product Overview: Recombinant Human PAX3 protein with C-His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.
• Molecular Mass: 54 kDa
• AA Sequence: MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNHGGVPHQPQTDYALSPLTGGLEPTTTVSASCSQRLDHMKSLDSLPTSQSYCPPTYSTTGYSMDPVTGYQYGQYGQSKPWTFHHHHHHHH
• Purity: > 90% by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.16 mg/mL
• Storage Buffer: 50mM Tris, 300mM NaCl, pH 7.0

Gene Information

• Gene Name: PAX3 paired box 3 [ Homo sapiens (human) ]
• Official Symbol: PAX3
• Synonyms: PAX3; paired box 3; paired box gene 3 (Waardenburg syndrome 1) , Waardenburg syndrome 1 , WS1; paired box protein Pax-3; HUP2; paired domain gene 3; paired domain gene HuP2; paired box homeotic gene 3; WS1; WS3; CDHS; MGC120381; MGC120382; MGC120383; MGC120384; MGC134778
• Gene ID: 5077
• mRNA Refseq: NM_000438
• Protein Refseq: NP_000429
• MIM: 606597
• UniProt ID: P23760