Recombinant Human PARP3, GST-tagged
| Cat.No. : | PARP3-27634TH |
| Product Overview : | Recombinant full length Human PARP3 with N terminal GST-tag expressed in a Baculovirus infected Sf9 cell expression system, 87 kDa. |
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| Description : | The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Conjugation : | GST |
| Tissue specificity : | Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus. |
| Biological activity : | Specific Activity: 207.5 U/mg. |
| Form : | Liquid |
| Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8 |
| Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
| Sequence Similarities : | Contains 1 PARP alpha-helical domain.Contains 1 PARP catalytic domain. |
| Full Length : | Full L. |
| Gene Name | PARP3 poly (ADP-ribose) polymerase family, member 3 [ Homo sapiens ] |
| Official Symbol | PARP3 |
| Synonyms | PARP3; poly (ADP-ribose) polymerase family, member 3; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) like 3 , ADPRTL3; poly [ADP-ribose] polymerase 3; ADPRT3; hPARP 3; IRT1; NAD+ ADP ribosyltransferase 3; pADPRT 3; poly(ADP ribose) polymerase |
| Gene ID | 10039 |
| mRNA Refseq | NM_001003931 |
| Protein Refseq | NP_001003931 |
| MIM | 607726 |
| Uniprot ID | Q9Y6F1 |
| Chromosome Location | 3p22.2-p21.1 |
| Pathway | BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; |
| Function | NAD+ ADP-ribosyltransferase activity; catalytic activity; transferase activity, transferring glycosyl groups; |
Not For Human Consumption!
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