Recombinant Human PAK6, GST-His

• Cat.No.: PAK6-724H
• Product Overview: Recombinant Human PAK6, full length, amino acids M1-C681, N-terminally fused to GST-HIS6-Thrombin cleavage site, expressed inSf9insect cells. MW = 104,780 Da.

Specification

• Cat. No.: PAK6-724H
• Description: PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development.
• Source: Baculovirus infected Sf9 cells.
• Purification: One-step affinity purification using GSH-agarose.
• Product Identity: PAK6 was confirmed as PAK6 by mass spectroscopy LC-ESI-MS/MS (Protagen AG, Germany).
• Storage Buffer: 50 mM HEPES-NaOH, pH 7.5; 100 mM NaCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol.
• Concentration: 0.082 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
• Specific Activity: 7 pmol/μg×min.
• Storage: -80°C. Avoid repeated freeze-thaw cycles!
• Protein length: 1-681 a.a.
• Full Length: Full L.

Gene Information

• Gene Name: PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 [ Homo sapiens ]
• Synonyms: PAK6; p21 protein (Cdc42/Rac)-activated kinase 6; PAK5; p21-activated kinase 6; p21(CDKN1A)-activated kinase 6; p21-activated protein kinase 6; EC 2.7.11.1
• Gene ID: 56924
• mRNA Refseq: NM_001128628
• Protein Refseq: NP_001122100
• MIM: 608110
• UniProt ID: Q9NQU5
• Chromosome Location: 15q14
• Pathway: Axon guidance; ErbB signaling pathway; Focal adhesion; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway
• Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity