Recombinant Human p21 Protein (Cdc42/Rac)-Activated Kinase 6, His-tagged

• Cat.No.: PAK6-1284H
• Product Overview: Recombinant humanfull length PAK6 is a serine/threonine kinase expressed in the testis andprostate. Itassociates with both the estrogen and androgen receptors. No special measureswere taken to activate this kinase. Itsmolecular weight is 79900 Dalton.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Description: Serine/threonine-proteinkinase PAK6 is an enzyme that in humans is encoded by the PAK6 gene. Thisgene encodes a protein that shares a high degree of sequence similarity withp21-activated kinase (PAK) family members. The proteins of this family areRac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by ahighly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domainand a carboxyl-terminal kinase domain. PAK kinases are implicated in theregulation of a number of cellular processes, including cytoskeletonrearrangement, apoptosis and the MAP kinase signaling pathway.
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
• Molecular Weight: 79.9 kDa
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: PAK6
• Full Length: Full L.

Gene Information

• Gene Name: PAK6 p21 protein (Cdc42/Rac)-activatedkinase 6 [ Homo sapiens ]
• Synonyms: PAK6; p21 protein(Cdc42/Rac)-activated kinase 6; PAK5; p21-activated kinase 6;p21(CDKN1A)-activated kinase 6; p21-activated protein kinase 6; EC 2.7.11.1;PAK-5; PAK-6; Serine/threonine-protein kinase PAK 6
• Gene ID: 56924
• mRNA Refseq: NM_020168
• Protein Refseq: NP_064553
• MIM: 608110
• UniProt ID: Q9NQU5
• Chromosome Location: 15q14
• Pathway: Activation of Rac;Androgen Receptor Signaling Pathway; Axon guidance; CDC42 signaling events;Developmental Biology; ErbB signaling pathway; Focal adhesion;Integrin-mediated cell adhesion; Regulation of actin cytoskeleton; Renal cellcarcinoma; Signaling by Robo receptor; T cell receptor signaling pathway
• Function: ATP binding;nucleotide binding; protein serine/threonine kinase activity