Recombinant Human PAK4, GST-tagged, Active

• Cat.No.: PAK4-380H
• Product Overview: Recombinant full-length human PAK4 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal GST tag. MW=90 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: PAK4 is a recently identified member of the p21-activated kinases (PAKs) which have been implicated in the regulation of cell morphology, motility and transformation. These serine/threonine kinases are activated by and are effectors of small GTPases, cdc 42 and Rac. PAK4 belongs to the Group II PAKs which also includes PAK5 and PAK6. PAK4 has been shown to regulate cell morphology and cytoskeletal organization in mammalian cells.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 [ Homo sapiens ]
• Synonyms: PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21-activated kinase 4; p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; Serine/threonine-protein kinase PAK 4; KIAA1142; EC 2.7.11.1; PAK-4
• Gene ID: 10298
• mRNA Refseq: NM_001014831
• Protein Refseq: NP_001014831
• MIM: 605451
• UniProt ID: O96013
• Chromosome Location: 19q13.2
• Pathway: Axon guidance; ErbB signaling pathway; Focal adhesion; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway
• Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity