PAK4
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Official Full Name
p21 protein (Cdc42/Rac)-activated kinase 4 -
Overview
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. -
Synonyms
PAK4 + PAK5 + PAK6;PAK4;p21 protein (Cdc42/Rac)-activated kinase 4;p21(CDKN1A) activated kinase 4;serine/threonine-protein kinase PAK 4;PAK-4;p21-activated kinase 4;p21(CDKN1A)-activated kinase 4;protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- Insect Cells
- Sf9 Cells
- HEK293
- Sf21 Cells
- His
- Non
- GST
- Flag
- Avi&Fc&His
- DDK&Myc
- His&SUMO
Involved Pathway
PAK4 involved in several pathways and played different roles in them. We selected most pathways PAK4 participated on our site, such as Activation of Rac,Axon guidance,CDC42 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| CDC42 signaling events | IQGAP3,CFL1,ARPC4,CDC42BPA,ACTR3,ARPC1B,ARPC2,TNK2,ARPC3,CTNNA1 |
| Axon guidance | EFNA2,SEMA3D,EFNB1,RAC1,DAB2IPB,ABLIM1,UNC5D,DUSP5,GSK3B,EFNB3B |
| Developmental Biology | EBF1,DUSP9,KDR,ARPC4,CACNG2,CHL1,TRPC4,LGI4,FOXD3,FOXH1 |
| Focal adhesion | FN1,PIK3CG,LAMC1,ROCK2,THBS4B,ITGB4,IGF1,PARVG,MAPK3,MAPK9 |
| ErbB signaling pathway | MAP2K7,PIK3CG,NCK1,PAK2,CAMK2D2,ABL1,RPS6KB2,PTK2,ERBB2,GSK3AA |
| FGF signaling pathway | SP8B,SP8A,BGLAP,EGR2B,FGFRL1B,FGFRL1A,SOX32,FGF24,EGR2A,SPRY2 |
Protein Function
PAK4 has several biochemical functions, for example, ATP binding,Rac GTPase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK4 itself. We selected most functions PAK4 had, and list some proteins which have the same functions with PAK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | BMPR1B,NME2B.1,PIK3CG,PRKAG3,CCT5,DNAH6,MYO6B,DHX32,NADSYN1,ATAD5B |
| protein binding | GEMIN8,IYD,FAM104A,CCND2,UBE2Z,ACTR8,CYS1,ZNF350,IL17RE,C12orf68 |
| protein kinase activity | ADRBK1,BRAF,PRKCZ,GUCY2C,DYRK3,SCYL2,PRKACAA,STK26,EGFRA,PHKG1B |
| protein serine/threonine kinase activity | DAPK2,STK4,PIM1,ALPK2,CAMK1GA,BSK146,RPS6KA4,MAPKAPK5,WNK1,NLK2 |
| Rac GTPase binding | PAK3,RAB7A,ARFIP2,RCC2,RAB7,DOCK4,ARHGEF2,PAK2A,NCF2,SRGAP2B |
Interacting Protein
PAK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK4.
YWHAZ;CDC42;YWHAG;YWHAB;TERF1;SRPK2;SRPK1;YWHAQ;SFN;LRRK1;ARHGEF2;DLST;GATAD2A
PAK4 Related Signal Pathway
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References
- Kesanakurti, D; Chetty, C; et al. Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma. CELL DEATH & DISEASE 3:-(2012).
- Zhang, HJ; Siu, MKY; et al. Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma. CARCINOGENESIS 32:765-771(2011).
