Recombinant Human p21 Protein (Cdc42/Rac)-Activated Kinase 4, GST-tagged

• Cat.No.: PAK4-1283H
• Product Overview: Recombinant humanPAK4 catalytic domain (amino acids 295-591), GST-tagged. Activated in vitrovia auto-phosphorylation. Its molecular weight is 61600 Dalton.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 295-591 a.a.
• Description: PAK proteins, afamily of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3and PAK4. PAK proteins are critical effectors that link Rho GTPases tocytoskeleton reorganization and nuclear signaling. They serve as targets forthe small GTP binding proteins Cdc42 and Rac and have been implicated in awide range of biological activities. PAK4 interacts specifically with theGTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases.PAK4 is a serine/threonine p21 activating kinase implicated in thereorganization of actin cytoskeleton and in the formation of filopodia.
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
• Molecular Weight: 61.6 kDa
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: PAK4

Gene Information

• Gene Name: PAK4 p21 protein (Cdc42/Rac)-activatedkinase 4 [ Homo sapiens ]
• Synonyms: PAK4; p21 protein(Cdc42/Rac)-activated kinase 4; p21-activated kinase 4; p21(CDKN1A)-activatedkinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs;Serine/threonine-protein kinase PAK 4; KIAA1142; EC 2.7.11.1; PAK-4
• Gene ID: 10298
• mRNA Refseq: NM_005884
• Protein Refseq: NP_005875
• MIM: 605451
• UniProt ID: O96013
• Chromosome Location: 19q13.2
• Pathway: Activation of Rac;Axon guidance; CDC42 signaling events; Developmental Biology; ErbB signalingpathway; Focal adhesion; Integrin-mediated cell adhesion; Regulation of actincytoskeleton; Renal cell carcinoma; Signaling by Robo receptor; Signalingevents mediated by Hepatocyte Growth Factor Receptor (c-Met); T cell receptorsignaling pathway
• Function: ATP binding;nucleotide binding; protein kinase activity; protein kinase binding; proteinserine/threonine kinase activity