Recombinant Human P21 Protein-activated Kinase 4, His-tagged

• Cat.No.: PAK4-105H
• Product Overview: Recombinant PAK4 protein was expressed in E.coli and purified by using conventional chromatography techniques,68.3 kDa (628 aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: PAK4 is a member of the group B family of p21-activated kinases (PAK). It"s identified as an effector protein for cell division cycle 42(Cdc42) and protein that play an important role in regulating cytoskeletal organization and cell morphology. Its expression is elevated in many cancer cell lines, and suggested that it plays an important role in tumorigenesis.
• Sequences of amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMFG KRKKRVEISA PSNFEHRVHT GFDQHEQKFT GLPRQWQSLI EESARRPKPL VDPACITSIQ PGAPKTIVRG SKGAKDGALT LLLDEFENMS VTRSNSLRRD SPPPPARARQ ENGMPEEPAT TARGGPGKAG SRGRFAGHSE AGGGSGDRRR AGPEKRPKSS REGSGGPQES SRDKRPLSGP DVGTPQPAGL ASGAKLAAGR PFNTYPRADT DHPSRGAQGE PHDVAPNGPS AGGLAIPQSS SSSSRPPTRA RGAPSPGVLG PHASEPQLAP PACTPAAPAV PGPPGPRSPQ REPQRVSHEQ FRAALQLVVD PGDPRSYLDN FIKIGEGSTG IVCIATVRSS GKLVAVKKMD LRKQQRRELL FNEVVIMRDY QHENVVEMYN SYLVGDELWV VMEFLEGGAL TDIVTHTRMN EEQIAAVCLA VLQALSVLHA QGVIHRDIKS DSILLTHDGR VKLSDFGFCA QVSKEVPRRK SLVGTPYWMA PELISRLPYG PEVDIWSLGI MVIEMVDGEP PYFNEPPLKA MKMIRDNLPP RLKNLHKVSP SLKGFLDRLL VRDPAQRATA AELLKHPFLA KAGPPASIVP LMRQNRTR
• Formulation: Liquid. In 50 mM Tris-HCl buffer (pH 8.0) containing 2 mM DTT
• Purity: > 90% by SDS - PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 [ Homo sapiens ]
• Synonyms: PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21-activated kinase 4;p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; Serine/threonine-protein kinase PAK 4; KIAA1142; EC 2.7.11.1; PAK-4
• Gene ID: 10298
• mRNA Refseq: NM_001014831
• Protein Refseq: NP_001014831
• MIM: 605451
• UniProt ID: O96013
• Chromosome Location: 19q13.2
• Pathway: Axon guidance; ErbB signaling pathway; Focal adhesion; Regulation of actin cytoskeleton; Renal cell carcinoma; T cell receptor signaling pathway
• Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity