Recombinant Human OAS1, His-tagged

• Cat.No.: OAS1-27767TH
• Product Overview: Recombinant full length Human OAS1, isoform p41 with N terminal His tag; 384 amino acids with a predicted MWt 43.9kDa including tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 364 amino acids
• Description: This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2-specific nucleotidyl transfer reactions to synthesize 2,5-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.
• Conjugation: HIS
• Molecular Weight: 43.900kDa inclusive of tags
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 10% Glycerol, 0.02% DTT
• Storage: Please see Notes section
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMMDLRNTPAKSLDKFIEDYL LPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVK GGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQ EIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQ LGEGVEFDVLPAFDALGQLTGSYKPNPQIYVKLIEECTDL QKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCK KKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLE LVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPV SSWILLVRPPASSLPFIPAPLHEA
• Sequence Similarities: Belongs to the 2-5A synthase family.

Gene Information

• Gene Name: OAS1 2-5-oligoadenylate synthetase 1, 40/46kDa [ Homo sapiens ]
• Official Symbol: OAS1
• Synonyms: OAS1; 2-5-oligoadenylate synthetase 1, 40/46kDa; 2,5 oligoadenylate synthetase 1 (40 46 kD) , OIAS; 2-5-oligoadenylate synthase 1; IFI 4; OIASI
• Gene ID: 4938
• mRNA Refseq: NM_001032409
• Protein Refseq: NP_001027581
• Uniprot ID: P00973
• Chromosome Location: 12q24.2
• Pathway: Cytokine Signaling in Immune system, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem
• Function: 2-5-oligoadenylate synthetase activity; ATP binding; double-stranded RNA binding; nucleotide binding; nucleotidyltransferase activity