OAS1
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Official Full Name
2-5-oligoadenylate synthetase 1, 40/46kDa -
Overview
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to;viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2-specific;nucleotidyl transfer reactions to synthesize 2,5-oligoadenylates (2-5As). These molecules activate latent RNase L,;which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene;family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility;to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
OAS1;2-5-oligoadenylate synthetase 1, 40/46kDa;2,5 oligoadenylate synthetase 1 (40 46 kD) , OIAS;2-5-oligoadenylate synthase 1;IFI 4;OIASI;E18/E16;p46/p42 OAS;2-5A synthase 1;2-5A synthetase 1;(2-5)oligo(A) synthase 1;2,5-oligo A synthetase 1
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Rat
- E.coli
- Human
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&TRxA
- His&SUMO
- His&T7
- His&Fc&Avi
Involved Pathway
OAS1 involved in several pathways and played different roles in them. We selected most pathways OAS1 participated on our site, such as Hepatitis C,Measles,Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with OAS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | C3,PER3,NFKBIB,CCL5,CSNK2A2A,PKZ,TBK1,HNRPK,CASP3A,ARNTL1A |
| Influenza A | IL18,VDAC1,HSPA1A,BLA,IFNA16,IL1A,FURIN,IL8L1,IFNA21,KPNA1 |
| Measles | TNFRSF10A,CBLB,IFNA8,HSPA6,IFNA10,EIF2AK4,CD209,IFNB1,TLR4,CD3D |
| Hepatitis C | IFNA1,TRP53,PIK3R1,IFNA13,CXCL8,IFNA8,CLDN1,BRAF,MAPK8,CLDN3 |
Protein Function
OAS1 has several biochemical functions, for example, 2-5-oligoadenylate synthetase activity,ATP binding,double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OAS1 itself. We selected most functions OAS1 had, and list some proteins which have the same functions with OAS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 2-5-oligoadenylate synthetase activity | OAS3,OAS1A,OAS2,OASL2 |
| ATP binding | AARSD1,SRC,PEX1,NADSYN1,STK24,VMHCL,JAK3,STYK1,AK1,DHX38 |
| metal ion binding | JAZF1,ANTXR1,ATP8B5,USP19,SCNM1-PS,DGKE,ERCC5,NR6A1B,RTEL1,SPNA1 |
| double-stranded RNA binding | SUPV3L1,DDX21,DGCR8,TFRC,TUBA1B,DDX58,DHX15,VIM,OAS1A,LRRFIP1 |
| protein binding | ZBTB5,FGD5,MLH3,PAN3,RFC2,AKAP17A,ECHS1,KIAA1279,ZNF230,TXNDC9 |
| zinc ion binding | CPM,RNF32,ZFAND6,CA4,MORC2A,MT1F,CSRP1,NHLRC1,ADH8A,TRIM3 |
Interacting Protein
OAS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OAS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of OAS1.
ACTN1;TRIM27;EXOC5;PRMT6;o89168_9hepc;WBSCR22;RPL30
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References
- Feng, XB; Huang, J; et al. Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus. CLINICAL RHEUMATOLOGY 34:71-79(2015).
- Colonne, PM; Sahni, A; et al. Suppressor of cytokine signalling protein SOCS1 and UBP43 regulate the expression of type I interferon-stimulated genes in human microvascular endothelial cells infected with Rickettsia conorii. JOURNAL OF MEDICAL MICROBIOLOGY 62:968-979(2013).
