Recombinant Human Nuclear Receptor Subfamily 1, Group I, Member 3

• Cat.No.: NR1I3-1278H
• Product Overview: Recombinant humanConstitutive Androstane Receptor, Ligand Binding Domain containing aminoacids 101-348.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 101-348 a.a.
• Description: NR1I3 was identified as amember of the orphan nuclear hormone receptor family in 1994. Althoughconstitutively acitve, it can be further activated by phenobarbitol-likecompounds, the most potent being the synthetic compound TCPOBOP. Uponactivation, NR1I3 regulates the xenobiotic drug metabolizing enzymes,cytochrome P450s.
• Form: Liquid in 20 mMTris-Cl, pH 8.0 + 20% glycerol + 100 mM KCl + 1 mM DTT + 0.2 mM EDTA.
• Purity: > 95%
• Applications: In vitro transcriptionassays; DNA-protein interaction assays; Protein-protein interaction assays.
• storage: Stablefor 1 year in working aliquots at -80°C. Avoidrepeated freeze-thaw cycles.
• OfficialSymbol: NR1I3
• Pathways: Gene Expression; Generic TranscriptionPathway; Glucocorticoid receptor regulatory network; Nuclear Receptortranscription pathway; Nuclear Receptors; Nuclear receptors in lipidmetabolism and toxicity

Gene Information

• Gene Name: NR1I3 nuclear receptor subfamily1, group I, member 3 [ Homo sapiens ]
• Synonyms: NR1I3; nuclear receptorsubfamily 1, group I, member 3; CAR; CAR1; MB67; MGC97144; MGC97209;MGC150433; constitutive androstane receptor; OTTHUMP00000032246; constitutiveactive receptor; orphan nuclear hormone receptor; constitutive activator ofretinoid response; Nuclear receptor subfamily 1 group I member 3; Orphannuclear receptor MB67; OTTHUMP00000032245
• Gene ID: 9970
• mRNA Refseq: NM_001077469
• Protein Refseq: NP_001070937
• MIM: 603881
• UniProt ID: Q14994
• Chromosome Location: 1q23.3
• Function: DNA binding; androgen receptor activity; ligand-dependentnuclear receptor activity; metal ion binding; receptor activity; sequence-specificDNA binding; sequence-specific DNA binding transcription factor activity; steroidhormone receptor activity; thyroid hormone receptor activity; transcriptioncoactivator activity; zinc ion binding