Recombinant Human Constitutive androstane receptor Hsp90 complex, GST-tagged

• Cat.No.: NR1I3-108H
• Product Overview: Recombinant Human GST-tagged Constitutive androstane receptor (CAR) consists of a 218 a.a. GST tag, a 13 a.a. flexible linker and 352 a.a. human CAR, Acc# NP_001070948. Human Constitutive androstane receptor ligand-binding domain (CAR) in complex with human Hsp90 was produced in insect cells co-infected with two recombinant baculoviruses. GST tagged CAR and Hsp90 are the major components of the complex.

Specification

• Description: Constitutive androstane receptor is also known as nuclear receptor subfamily 1, group I, member 3 (NR1I3). In the cytoplasm it is found in complexes with Hsp90 which suggests its involvement in the receptor function.
• Source: Sf9 insect cells
• Species: Human
• Tag: GST
• Form: 20 mM Na-P pH 8.0, 40 mM KCl, 20 mM Na2MoO4, 7 mM reduced glutathione, 15% glycerol.
• Purity: >70%
• Applications: Ligand binding and coactivator peptide recruitment assays.
• Storage: Immediately store at -80℃. Avoid freeze-thaw cycles.While working, please keep sample on ice.

Gene Information

• Gene Name: NR1I3 nuclear receptor subfamily 1, group I, member 3 [ Homo sapiens ]
• Official Symbol: NR1I3
• Synonyms: NR1I3; nuclear receptor subfamily 1, group I, member 3; nuclear receptor subfamily 1 group I member 3; CAR; CAR1; constitutive androstane receptor; MB67; constitutive active receptor; constitutive active response; orphan nuclear receptor MB67; orphan nuclear hormone receptor; constitutive activator of retinoid response; constitutive androstane nuclear receptor variant 2; constitutive androstane nuclear receptor variant 3; constitutive androstane nuclear receptor variant 4; constitutive androstane nuclear receptor variant 5; MGC97144; MGC97209; MGC150433
• Gene ID: 9970
• mRNA Refseq: NM_001077469
• Protein Refseq: NP_001070937
• MIM: 603881
• Chromosome Location: 1q23.3
• Pathway: Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear Receptors, organism-specific biosystem; Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem
• Function: DNA binding; androgen receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metal ion binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; thyroid hormone receptor activity; transcription coactivator activity; zinc ion binding