NR1I3
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Official Full Name
NR1I3 nuclear receptor subfamily 1, group I, member 3 -
Synonyms
NR1I3;nuclear receptor subfamily 1, group I, member 3;nuclear receptor subfamily 1 group I member 3;CAR;CAR1;constitutive androstane receptor;MB67;constitutive active receptor;constitutive active response;orphan nuclear receptor MB67;orphan nuclear hormone receptor;constitutive activator of retinoid response;constitutive androstane nuclear receptor variant 2;constitutive androstane nuclear receptor variant 3;constitutive androstane nuclear receptor variant 4;constitutive androstane nuclear receptor variant 5;MGC97144;MGC97209;MGC150433
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Rat
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- Non
- GST
- His
- Avi
- Fc
- SUMO
Involved Pathway
NR1I3 involved in several pathways and played different roles in them. We selected most pathways NR1I3 participated on our site, such as Drug Induction of Bile Acid Pathway,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1I3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glucocorticoid receptor regulatory network | SMARCA4,KRT14,POU2F1,EGR1,SMARCD1,KRT5,CSN2,KRT17,SMARCC2,BGLAP |
| Drug Induction of Bile Acid Pathway | SLC51B,CYP7A1,SLCO1B1,NR1I2,ABCC2 |
| Generic Transcription Pathway | COX16,ZNF18,ZNF573,NRBF2,ZNF92,COX6B1,ZKSCAN1,ZNF189,JUNB,ZNF133 |
| Gene Expression | IGF2BP3,HNRNPA0A,GTF3C5,CHD4A,EED,PUS7,NR2F1,ZNF776,CDK9,COBRA1 |
| Nuclear receptors in lipid metabolism and toxicity | CYP27B1,ABCC2,VDRB,NR1I2,RARG,CYP26A1,RARGA,CYP24A1,RARGB |
| Nuclear Receptor transcription pathway | NRBP1,NR2E3,NR2F6A,NR5A1A,RARGA,NR2F1A,RORAA,NR5A1,RARAB,NR2F1B |
| Nuclear Receptors | RARGA,NR2C2,NR2F1A,RORAA,VDRB,NR1D2,NR1D2B,NR2F2,ROR1,NR0B1 |
Protein Function
NR1I3 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1I3 itself. We selected most functions NR1I3 had, and list some proteins which have the same functions with NR1I3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | GATA1A,CDX1B,ARHGAP35,NHLH1,RARA,OSR2,CEBPB,PRDM15,KLF12,ZNF584 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MSGN1,CREB3L4,EAF2,STAG1,CSRNP2,CSRNP1,BHLHA15,IRF2,DMRT1,REST |
| transcription factor activity, sequence-specific DNA binding | ATF6,WT1,KAT7,MYCH,NFIC,KLF2,NEUROD1,HNF1BA,MSRB2,NR5A1A |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | NR5A1B,NR1D2,NR2F1,RORCB,NR4A2,NR4A2B,VDRA,ESRRA,NR4A2A,RORAB |
| androgen receptor activity | Ar,NKX3-1,NKX3 |
| zinc ion binding | TRIM35-1,RNF181,Shh,CALB1,NPEPPS,MMP9,RNF220A,BAZ1A,L3MBTL4,SUV39H1B |
| thyroid hormone receptor activity | THRB,THRAA,NR2F6,NR1D4A,THRA,NR1D2A,NR4A3,NR1D4B,NR1H4,BRD8 |
| transcription coactivator activity | KAT6A,JUN,MTDH,PCBD1,BIRC2,CALCOCO1,PER2,TAF7L,CEBPA,GATA3 |
| DNA binding | IRF7,THAP3,MSH2,ZFP36L3,LTF,FOXB1A,DRAP1,POLR3F,ZMYM4,HMGB3A |
Interacting Protein
NR1I3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1I3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1I3.
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