Recombinant Human NR1H3 Protein, His-tagged

• Cat.No.: NR1H3-159H
• Product Overview: Recombinant Human NR1H3(Asn95~Lys434) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• ProteinLength: Asn95~Lys434
• Description: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 41kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS or others

Gene Information

• Gene Name: NR1H3 nuclear receptor subfamily 1, group H, member 3 [ Homo sapiens ]
• Official Symbol: NR1H3
• Synonyms: NR1H3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; liver X receptor alpha; LXR a; RLD 1; liver X nuclear receptor alpha variant 1; LXRA; LXR-a; RLD-1
• Gene ID: 10062
• mRNA Refseq: NM_001130101
• Protein Refseq: NP_001123573
• MIM: 602423
• UniProt ID: Q13133