NR1H3
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Official Full Name
NR1H3 nuclear receptor subfamily 1, group H, member 3 -
Synonyms
NR1H3;nuclear receptor subfamily 1, group H, member 3;oxysterols receptor LXR-alpha;liver X receptor alpha;LXR a;RLD 1;liver X nuclear receptor alpha variant 1;LXRA;LXR-a;RLD-1
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Bovine
- Mouse
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- His&SUMO
- His&Myc
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
NR1H3 involved in several pathways and played different roles in them. We selected most pathways NR1H3 participated on our site, such as Adipogenesis,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1H3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nuclear Receptor transcription pathway | NRBF2B,NR1D2B,RARG,NR1D2,RARAA,NR2C2AP,NR6A1,NR2C1,VDRB,NR5A1B |
| Adipogenesis | FRZB,NR2F1,HMGA1,CYP26A1,HMGA1-RS1,CISD1,NCOA2,EGR2,FOXC2,MBNL1 |
| Insulin resistance | MAPK8B,GSK3AA,NFKBIA,PPP1CAB,PPP2R4,CREB3L2,PYGM,PIK3CD,PIK3R3,MTOR |
| Hepatitis C | IRF3,RIPK1,PPP2CA,MAPK3,GSK3B,MAPK10,PIK3CD,CD81,MAPK13,CLDN5 |
| Gene Expression | ZNF37A,ZNF726,ZNF544,GTF3AA,NR6A1,EEF1D,C2orf29,SESN3,COX8A,ZNF189 |
| Generic Transcription Pathway | ZNF222,ZNF37A,CCNT2A,NR2E3,CDK8,ZNF692,COX4I1,ZNF548,ZFP30,ZNF566 |
| Nuclear Receptors | NR2E1,NR2F6,RARG,NR1I2,RORAA,VDRB,RARGA,NR2F1,NR4A2A,ROR1 |
| Non-alcoholic fatty liver disease (NAFLD) | SREBF1,NDUFA8,NDUFS2,NDUFB3,Casp3,NDUFB8,COX6A2,NDUFB4,TGFB1,AKT2 |
Protein Function
NR1H3 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding,cholesterol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1H3 itself. We selected most functions NR1H3 had, and list some proteins which have the same functions with NR1H3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cholesterol binding | ERLIN1,OSBPL10,ABCG1,OSBPL2,PROM2,NPC1,OSBPL7,NPC2,ANXA6,PMP2 |
| transcription coactivator activity | SETD3,TUBB3,ACTL6B,FHL2,ABT1,EDF1,NPM1,SUPT3H,TDRD3,ASXL1 |
| sequence-specific DNA binding | OTPA,CAMTA1,ESR2B,NCOR1,ZBTB14,VRTN,SALL2,SOX21A,FOXP1B,FOXP3 |
| zinc ion binding | RBM20,ZFAND4,CPSF4,ACE2,ZKSCAN5,ING3,RARAB,CPM,DHH,TRIM26 |
| sterol response element binding | SREBF1 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | PPARAB,RORCA,PPARA,RORC,NR2E3,NR1H4,Ar,ESRRA,NR0B1,RORCB |
| protein binding | MSH2,LAMTOR2,PSMA4,GRIA1,PGF,DHX58,NAT10,DOCK2,ERBB2,KIAA1199 |
| contributes_to transcription regulatory region DNA binding | HAND1,TCF3,TAF1,NFYC,HDAC4,NFYA,RXRA,TCF12,ATF4,HDAC5 |
| transcription regulatory region DNA binding | FOXA2,XRCC6,SALL2,MTERF3,ATF3,NFE2L2,SERPINB1A,SALL4,BRCA1,TP73 |
Interacting Protein
NR1H3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1H3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1H3.
RXRG;NCOA1
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References
- Constantinopoulos, P; Michalaki, M; et al. Cortisol in tissue and systemic level as a contributing factor to the development of metabolic syndrome in severely obese patients. EUROPEAN JOURNAL OF ENDOCRINOLOGY 172:-(2015).
- Xia, X; Qu, B; et al. Analyzing time-series microarray data reveals key genes in spinal cord injury. MOLECULAR BIOLOGY REPORTS 41:6827-6835(2014).
