Recombinant Human NR1H3, GST-tagged

• Cat.No.: NR1H3-116H
• Product Overview: Recombinant Human GST-tagged Liver X receptor alpha ligand-binding domain (LXRA-LBD) consists of a 218 a.a. GST tag, a 13 a.a. flexible linker and a 241 a.a. LXRA-LBD, Acc# NP_005684.2, amino acids 207-447, was expressed in baculovirus-infected insect cells and purified using affinity chromatography.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: Liver X receptor alpha (LXR-alpha or LXRA) is also known as oxysterols receptor or NR1H3 (nuclear receptor subfamily 1, group H, member 3).
• Form: 50 mM Tris-HCl pH 8.0, 150 mM NaCl, 0.5 mM EDTA, 3 mM Dithiothreitol, 7 mM reduced glutathione, 20% glycerol.
• Purity: >90%
• Applications: Ligand binding and coactivator peptide recruitment assays.
• Storage: Immediately store at -80℃. Avoid freeze-thaw cycles.While working, please keep sample on ice.

Gene Information

• Gene Name: NR1H3 nuclear receptor subfamily 1, group H, member 3 [ Homo sapiens ]
• Official Symbol: NR1H3
• Synonyms: NR1H3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; liver X receptor alpha; LXR a; RLD 1; liver X nuclear receptor alpha variant 1; LXRA; LXR-a; RLD-1
• Gene ID: 10062
• mRNA Refseq: NM_001130101
• Protein Refseq: NP_001123573
• MIM: 602423
• UniProt ID: Q13133
• Chromosome Location: 11p11.2
• Pathway: Adipogenesis, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear Receptors, organism-specific biosystem
• Function: DNA binding; cholesterol binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metal ion binding; protein binding; protein heterodimerization activity; receptor activity; retinoid X receptor binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; sterol response element binding; transcription coactivator activity; transcription regulatory region DNA binding; contributes_to transcription regulatory region DNA binding; transcription regulatory region DNA binding; zinc ion binding