Recombinant Human NMNAT3, His-tagged

• Cat.No.: NMNAT3-639H
• Product Overview: Recombinant Human NMNAT3 is produced inE.coliand fused at the N-terminus to a His-tag. MW=30.3kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD.
• Purity: ≥95% (SDS-PAGE).
• Formulation: Liquid. In 50mM sodium phosphate, pH 8.0, containing 300mM sodium chloride, 1mM DTT and 10% glycerol.
• Application: Well suited for the synthesis of NAD analogs due to lower substrate selectivity compared to NMNAT1.
• Storage And Stability: -20°C. Stable for at least 3 months after receipt when stored at -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: NMNAT3 nicotinamide nucleotide adenylyltransferase 3 [ Homo sapiens ]
• Synonyms: NMNAT3; nicotinamide nucleotide adenylyltransferase 3; PNAT3; EC 2.7.7.1; EC 2.7.7.18
• Gene ID: 349565
• mRNA Refseq: NM_178177
• Protein Refseq: NP_835471
• MIM: 608702
• UniProt ID: Q96T66
• Chromosome Location: 3q23
• Pathway: Metabolic pathways; Nicotinate and nicotinamide metabolism; Metabolism of vitamins and cofactors
• Function: ATP binding; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; nucleotide binding; nucleotidyltransferase activity; protein binding; transferase activity