NMNAT3
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Official Full Name
nicotinamide nucleotide adenylyltransferase 3 -
Overview
This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
NMNAT3;nicotinamide nucleotide adenylyltransferase 3;nicotinamide mononucleotide adenylyltransferase 3;PNAT3;NaMN adenylyltransferase 3;Nicotinate-nucleotide adenylyltransferase 3;NMN adenylyltransferase 3;NMNA3_HUMAN;NMNAT 3;PNAT 3;PNAT-3;Pyridine nucleotide adenylyltransferase 3;FKSG76
Recombinant Proteins
- Mouse
- Human
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- His&SUMO
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NMNAT3-10749M | Recombinant Mouse NMNAT3 Protein | Mammalian Cells | Mouse | His |
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| NMNAT3-639H | Recombinant Human NMNAT3, His-tagged | E.coli | Human | His |
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| NMNAT3-1201HCL | Recombinant Human NMNAT3 cell lysate | Human | Non |
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| NMNAT3-4679H | Recombinant Human NMNAT3 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-215aa |
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| NMNAT3-5942H | Recombinant Human NMNAT3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| NMNAT3-6115M | Recombinant Mouse NMNAT3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NMNAT3-6115M-B | Recombinant Mouse NMNAT3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| NMNAT3-6597HF | Recombinant Full Length Human NMNAT3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 215 amino acids |
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Involved Pathway
NMNAT3 involved in several pathways and played different roles in them. We selected most pathways NMNAT3 participated on our site, such as Nicotinate and nicotinamide metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NMNAT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ST8SIA5,UCK1,MAN1A2,GAD1B,PSAT1,B3GALT6,POLR3D,NAPRT1,ITPA,KYNU |
| Nicotinate and nicotinamide metabolism | KCNG4,NNMT,AOX1,QPRT,MIBP,NNT,AOX4,NT5C2,BST1,NT5C2B |
Protein Function
NMNAT3 has several biochemical functions, for example, ATP binding,nicotinamide-nucleotide adenylyltransferase activity,nicotinate-nucleotide adenylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NMNAT3 itself. We selected most functions NMNAT3 had, and list some proteins which have the same functions with NMNAT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nicotinate-nucleotide adenylyltransferase activity | NMNAT1,ABL1,NMNAT2 |
| ATP binding | P2RX7,ASNS,ATP2B3A,TLK1B,CDKL2,TWF2,DDX18,TOP2A,SYN2,TARS |
| nicotinamide-nucleotide adenylyltransferase activity | NMNAT2,NMNAT1 |
Interacting Protein
NMNAT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NMNAT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NMNAT3.
Resources
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References
- Knepper, A; Schleicher, M; et al. Enhancement of the NAD(P)(H) pool in Saccharomyces cerevisiae. ENGINEERING IN LIFE SCIENCES 8:381-389(2008).
- Franchetti, P; Pasqualini, M; et al. Stereoselective synthesis of nicotinamide beta-riboside and nucleoside analogs. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14:4655-4658(2004).
