Recombinant Human NEK6 Protein (A2-T313), GST tagged

• Cat.No.: NEK6-0908H
• Product Overview: Recombinant Human GST-TEV-GG-NEK6(A2-T313 end) Protein was expressed in Insect cell.

Specification

• Description: Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression.
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: Liquid
• Protein length: A2-T313
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: NEK6 NIMA (never in mitosis gene a)-related kinase 6 [ Homo sapiens (human) ]
• Official Symbol: NEK6
• Synonyms: NEK6; NIMA (never in mitosis gene a)-related kinase 6; SID6-1512
• Gene ID: 10783
• mRNA Refseq: NM_014397
• Protein Refseq: NP_055212
• MIM: 604884
• UniProt ID: Q9HC98