Recombinant Human NDUFS4

• Cat.No.: NDUFS4-367H
• Product Overview: Recombinant Human NDUFS4 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 134 amino acids (43-175 a.a.) and having a molecular mass of 15.5 kDa. The NDUFS4 is purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• ProteinLength: 43-175 a.a.
• Description: NDUFS4 is a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), the primary multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I is involved in cellular ATP production, the main source of energy for numerous vital processes in living cells. NDUFS4 removes electrons from NADH and passes them by a series of diverse protein-coupled redox centers to the electron acceptor ubiquinone. NDUFS4 presents a hotspot of mutations in the genetic apparatus of oxidative phosphorylation and the correct assembly of the subunit it encodes is essential for completion of the assembly of complex I.
• Amino Acid Sequence: MAQDQTQDTQ LITVDEKLDI TTLTGVPEEH IKTRKVRIFV PARNNMQSGV NNTKKWKMEF DTRERWENPL MGWASTADPL SNMVLTFSTK EDAVSFAEKN GWSYDIEERK VPKPKSKSYG ANFSWNKRTR VSTK.
• Physical Appearance: Sterile Filtered colorless solution.
• Formulation: The NDUFS4 solution contains 20mM Tris pH-8 & 30% glycerol.
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Stability: NDUFS4 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) [ Homo sapiens ]
• Synonyms: NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe-S protein 4; NADH dehydrogenase (ubiquinone) iron-sulfur protein 4; NADH-coenzyme Q reductase, 18-KD; NADH-ubiquinone oxidoreductase 18 kDa subunit; mitochondrial respiratory chain complex I (18-KD subunit); AQDQ
• Gene ID: 4724
• mRNA Refseq: NM_002495
• Protein Refseq: NP_002486
• MIM: 602694
• UniProt ID: O43181
• Chromosome Location: 5q11.1
• Pathway: Alzheimer"s disease; Huntington"s disease; Metabolic pathways; Metabolic pathways; Parkinson"s disease; Diabetes pathways; Electron Transport Chain; Integration of energy metabolism
• Function: NADH dehydrogenase (ubiquinone) activity; oxidoreductase activity, acting on NADH or NADPH