NDUFS4

  • Official Full Name

    NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)

  • Overview

    This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes.

  • Synonyms

    NDUFS4;NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase);NADH dehydrogenase (ubiquinone) Fe S protein 4 (18kD) (NADH coenzyme Q reductase);NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial;AQDQ;CI 18

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • GST
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
NDUFS4-1240H Recombinant Human NDUFS4, His-tagged E.coli Human His 1-175aa
NDUFS4-2509H Recombinant Human NADH Dehydrogenase (ubiquinone) Fe-S Protein 4, 18kDa (NADH-coenzyme Q reductase) E.coli Human Non 43-175aa
NDUFS4-28208TH Recombinant Human NDUFS4 E.coli Human Non 133 amino acids
NDUFS4-2842Z Recombinant Zebrafish NDUFS4 Mammalian Cells Zebrafish His
NDUFS4-29482TH Recombinant Human NDUFS4 E.coli Human Non Full L. 43-175 a.a.
NDUFS4-367H Recombinant Human NDUFS4 E.coli Human Non 43-175 a.a.
NDUFS4-3944R Recombinant Rat NDUFS4 Protein Mammalian Cells Rat His
NDUFS4-3895HCL Recombinant Human NDUFS4 293 Cell Lysate HEK293 Human Non
NDUFS4-301403H Recombinant Human NDUFS4 protein, GST-tagged E.coli Human GST Ala115-Lys175
NDUFS4-3602R Recombinant Rat NDUFS4 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
NDUFS4-3602R-B Recombinant Rat NDUFS4 Protein Pre-coupled Magnetic Beads HEK293 Rat
Ndufs4-4346M Recombinant Mouse Ndufs4 Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK

    Involved Pathway

    NDUFS4 involved in several pathways and played different roles in them. We selected most pathways NDUFS4 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Parkinsons disease SLC25A6,SDHC,NDUFA5,DRD1A,COX6B2,NDUFA2,MT-ND1,GNAI1,UBE2J2,UQCRC1
    Alzheimers disease NDUFA13,CALML5,ATP5G1,NDUFA4L2,CALML3,IL1B2,MME,CALM2,CHP,PSENEN
    Non-alcoholic fatty liver disease (NAFLD) COX7A1,AKT2,NDUFA10,IKBKB,PIK3CB,MAPK10,UQCR10,SDHB,NDUFB6,CYCS
    Oxidative phosphorylation UQCRC2B,NDUFA11,ATP6V1E1,ATP6V1H,ATP5F1,NDUFS8B,NDUFS8A,NDUFA9,ATP6V0A1A,ATP6V1B1
    Metabolic pathways GALNT10,SPTLC2B,UQCRB,CYP2U1,ADO,HAL,CYP2B6,GPT2L,IDH1,C1GALT1B
    Huntingtons disease PLCB4,POLR2C,VDAC3,APAF1,TFAM,DNAL4,SDHC,ATP5D,UQCRC1,POLR2J

    Protein Function

    NDUFS4 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity,contributes_to NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS4 itself. We selected most functions NDUFS4 had, and list some proteins which have the same functions with NDUFS4. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to NADH dehydrogenase (ubiquinone) activity NDUFS8,NDUFS1
    NADH dehydrogenase (ubiquinone) activity NDUFS6,NDUFA8,NDUFB1,NDUFS2,NDUFS7,NDUFB2,NDUFA3,NDUFB3,NDUFS5,NDUFA13

    Interacting Protein

    NDUFS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS4.

    NDUFA2;UBE2G2;NDUFS8;COX7A2L;NDUFS5;NDUFS2;NDUFS3;NDUFB4;NDUFB8;NDUFA7;NDUFB10;MT-ND1;MT-ND4;MT-ND5;NDUFV2;NDUFS1;NDUFV1;NDUFV3

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