Recombinant Human NCK Adaptor Protein 1, His-tagged

• Cat.No.: NCK1-1473H
• Product Overview: Recombinant full-length human NCK was expressed by baculovirus inSf9 insect cellsusing an N-terminal His tag. MW = 48 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Description: NCK (or non-catalytic region of tyrosine kinase adaptor protein 1 is an adaptor protein that is located in the cytoplasm and involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. NCK is a signaling and transforming protein that contains Src homology 2 and 3 (SH2 and SH3) domains. NCK functions by coupling tyrosine phosphorylation via SH2 domains to downstream effectors through SH3 domains. Furthermore, NCK couples tyrosine phosphorylation guidance signals to cytoskeletal events required for the ipsilateral projections of spinal cord neurons and for normal limb movement.
• Sequence: Full-length.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: NCK1 NCK adaptor protein 1 [ Homo sapiens ]
• Synonyms: NCK1; NCK adaptor protein 1; NCK; MGC12668; NCKalpha; NCK tyrosine kinase; melanoma NCK protein; SH2/SH3 adaptor protein NCK-alpha; non-catalytic region of tyrosine kinase; Nck-1; Cytoplasmic protein NCK1
• Gene ID: 4690
• mRNA Refseq: NM_006153
• Protein Refseq: NP_006144
• MIM: 600508
• UniProt ID: P16333
• Chromosome Location: 3q21
• Pathway: Axon guidance; ErbB signaling pathway; Pathogenic Escherichia coli infection; T cell receptor signaling pathway
• Function: cytoskeletal adaptor activity; protein domain specific binding; receptor binding; receptor signaling complex scaffold activity