Recombinant Human NCK1, His-tagged

• Cat.No.: NCK1-29297TH
• Product Overview: Recombinant full length Human Nck with N terminal His tag, expressed in a Baculovirus infected Sf9 cell expression system, MWt 48kDa.

Specification

• Species: Human
• Tag: His
• Description: The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
• Conjugation: HIS
• Form: Liquid
• Storage buffer: Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 2mM DTT, 0.1mM PMSF, pH 7.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 1 SH2 domain.Contains 3 SH3 domains.
• Full Length: Full L.

Gene Information

• Gene Name: NCK1 NCK adaptor protein 1 [ Homo sapiens ]
• Official Symbol: NCK1
• Synonyms: NCK1; NCK adaptor protein 1; NCK; cytoplasmic protein NCK1; NCKalpha
• Gene ID: 4690
• mRNA Refseq: NM_001190796
• Protein Refseq: NP_001177725
• MIM: 600508
• Uniprot ID: P16333
• Chromosome Location: 3q21
• Pathway: Activation of Rac, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Axon guidance, organism-specific biosystem
• Function: cytoskeletal adaptor activity; protein binding; protein domain specific binding; receptor binding; receptor signaling complex scaffold activity