Recombinant Human NCALD, His-tagged
Cat.No. : | NCALD-27853TH |
Product Overview : | Recombinant full length Human NCALD , with an N terminal His tag ; predicted mwt: 24.4 kDa. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | 193 amino acids |
Description : | This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. |
Conjugation : | HIS |
Molecular Weight : | 24.400kDa inclusive of tags |
Tissue specificity : | Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine. |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 40% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, 1mM DTT, pH 8 |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK IYGNFFPYGD ASKFAEHVFRTFDANGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISKAE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNRDGKLSLEEFI RGAKSDPSIV RLLQCDPSSA GQF |
Sequence Similarities : | Belongs to the recoverin family.Contains 4 EF-hand domains. |
Gene Name | NCALD neurocalcin delta [ Homo sapiens ] |
Official Symbol | NCALD |
Synonyms | NCALD; neurocalcin delta; neurocalcin-delta; |
Gene ID | 83988 |
mRNA Refseq | NM_001040624 |
Protein Refseq | NP_001035714 |
MIM | 606722 |
Uniprot ID | P61601 |
Chromosome Location | 8q22-q23 |
Pathway | Activation of Ca-permeable Kainate Receptor, organism-specific biosystem; Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem; Ionotropic activity of Kainate Receptors, organism-specific biosystem; Neuronal System, organism-specific biosystem; Neurotransmitter Receptor Binding And Downstream Transmission In ThePostsynaptic Cell, organism-specific biosystem; |
Function | actin binding; calcium ion binding; clathrin binding; tubulin binding; |
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Not For Human Consumption!
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