Recombinant Human NCALD, His-tagged

Cat.No. : NCALD-27853TH
Product Overview : Recombinant full length Human NCALD , with an N terminal His tag ; predicted mwt: 24.4 kDa.
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Species : Human
Source : E.coli
Tag : His
Protein Length : 193 amino acids
Description : This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined.
Conjugation : HIS
Molecular Weight : 24.400kDa inclusive of tags
Tissue specificity : Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 40% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, 1mM DTT, pH 8
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK IYGNFFPYGD ASKFAEHVFRTFDANGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISKAE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNRDGKLSLEEFI RGAKSDPSIV RLLQCDPSSA GQF
Sequence Similarities : Belongs to the recoverin family.Contains 4 EF-hand domains.
Gene Name NCALD neurocalcin delta [ Homo sapiens ]
Official Symbol NCALD
Synonyms NCALD; neurocalcin delta; neurocalcin-delta;
Gene ID 83988
mRNA Refseq NM_001040624
Protein Refseq NP_001035714
MIM 606722
Uniprot ID P61601
Chromosome Location 8q22-q23
Pathway Activation of Ca-permeable Kainate Receptor, organism-specific biosystem; Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem; Ionotropic activity of Kainate Receptors, organism-specific biosystem; Neuronal System, organism-specific biosystem; Neurotransmitter Receptor Binding And Downstream Transmission In ThePostsynaptic Cell, organism-specific biosystem;
Function actin binding; calcium ion binding; clathrin binding; tubulin binding;

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