Ifna
-
Official Full Name
glycoprotein hormones, alpha polypeptide/chorionic gonadotropin, beta polypeptide -
Overview
Chorionic Gonadotropin (hCG) is a glycoprotein hormone which is normally produced by the placenta during pregnancy. After conception, the hCG concentration increases rapidly to reach a peak near the end of the first trimester. High concentrations are observed throughout pregnancy. After delivery, hCG levels fall rapidly and become undetectable after a few days. Structurally intact hCG molecules are composed of an alpha and a beta subunit. The alpha subunit is nearly identical to the alpha subunits of other glycoprotein hormones, such as Thyroid Stimulating Hormone (TSH), Luteinizing Hormone (LH), and Follicle Stimulating Hormone (FSH): The differences in the beta subunit of the respective hormones account for their biological specificity and immunochemical distinctiveness. Monoclonal antibodies recognizing unique sites on the beta chain of the β-hCG/hCG molecule are essential for differentiation between hCG and LH, FSH and TSH. Specific assays for beta-hCG permit the early detection of pregnancy. In addition to the elevated hCG levels during pregnancy, high concentrations of βhCG/hCG may be associated with neoplasms of trophoblastic and nontrophoblastic origin such as hydatiform mole, chorionepithelioma, embryonal cell carcinoma, seminoma and many others. Human type I interferons comprise a vast and growing group of IFN proteins. All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains. Homologous molecules to type I IFNs are found in many species, including all mammals, and some have been identified in birds, reptiles, amphibians and fish species. The IFN-α proteins are produced by leukocytes. They are mainly involved in innate immune response against viral infection. They come in 13 subtypes that are called IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21. These genes for these IFN-α molecules are found together in a cluster on chromosome 9. IFN-α is also made synthetically as medication. Types are: Pegylated interferon alfa-2a Pegylated interferon alfa-2b -
Synonyms
HCG/CGB;human chorionic gonadotropin/Chorionic Gonadotropin, Beta Polypeptide;interferon-alpha;IFNaA;IFN-a;interferon alpha-A;interferon alpha A;Ifna;interferon alpha
Recombinant Proteins
- Chicken
- Bovine
- Goat
- Cotton Rat
- Mouse
- Canine
- Rabbit
- Human
- Rhesus macaque
- Rat
- Cynomolgus
- Ferret
- Sheep
- E.coli
- Yeast
- HEK293
- Mammalian Cells
- Non
- His
- GST&His
- Avi&Fc&His
- His&T7
- DDK&Myc
- GST
Involved Pathway
Ifna involved in several pathways and played different roles in them. We selected most pathways Ifna participated on our site, such as Type II interferon signaling (IFNG), which may be useful for your reference. Also, other proteins which involved in the same pathway with Ifna were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Type II interferon signaling (IFNG) | IFI6,GBP1,IFIT2,REG1A |
Protein Function
Ifna has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Ifna itself. We selected most functions Ifna had, and list some proteins which have the same functions with Ifna. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
Ifna has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ifna here. Most of them are supplied by our site. Hope this information will be useful for your research of Ifna.
Ifna Related Signal Pathway
Resources
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References
