Recombinant Human Nascent Polypeptide-Associated Complex Alpha Subunit, His-tagged

• Cat.No.: NACA-1286H
• Product Overview: Recombinant human NACA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: Human
• Tag: His
• Description: NACA is member of the nascent polypeptide associated complex (NAC) alpha subunit family that participate in preventing inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Most NACA proteins localize to both nucleus as well as cytoplasm, and contain NAC-A/B (NAC-alpha/beta) and UBA (ubiquitin-associated) domains. The UBA domain is associated with proteins involved in the ubiquitin-proteasome pathway for protein degradation.
• Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT, 0.15M NaCl.
• Molecular Weight: 25.5 kDa (235aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
• Purity: > 95 % by SDS - PAGE
• Concentration: 1 mg/ml (determined by BCA)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MPGEATETVP ATEQELPQPQ AETGSGTESD SDESVPELEE QDSTQATTQQ AQLAAAAEID EEPVSKAKQS RSEKKARKAM SKLGLRQVTG VTRVTIRKSK NILFVITKPD VYKSPASDTY IVFGEAKIED LSQQAQLAAA EKFKVQGEAV SNIQENTQTP TVQEESEEEE VDETGVEVKD IELVMSQANV SRAKAVRALK NNSNDIVNAI MELTM
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: NACA nascent polypeptide-associated complex alpha subunit [ Homo sapiens ]
• Official Symbol: NACA
• Synonyms: NACA; nascent polypeptide-associated complex alpha subunit; HSD48; NACA1; MGC117224; nascent polypeptide-associated complex subunit alpha; NAC-alpha; alpha-NAC; Alpha-NAC; Allergen Hom s 2; nascent-polypeptide-associated complex alpha polypeptide; Nascent polypeptide-associated complex subunit alpha
• Gene ID: 4666
• mRNA Refseq: NM_001113201
• Protein Refseq: NP_001106672
• MIM: 601234
• UniProt ID: Q13765
• Chromosome Location: 12q23-q24.1
• Function: DNA binding