NACA

  • Official Full Name

    nascent polypeptide-associated complex alpha subunit

  • Overview

    The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene.

  • Synonyms

    NACA;nascent polypeptide-associated complex alpha subunit;nascent polypeptide associated complex alpha polypeptide;nascent polypeptide-associated complex subunit alpha;NACA1;Alpha NAC;Alpha-NAC;Hom s 2.02;HSD48;MGC117224;NAC-alpha;NACA/1.9.2;NACA_HUMAN;Nascent polypeptide associated complex alpha subunit;Nascent polypeptide associated complex subunit alpha;OTTHUMP00000242658;OTTHUMP00000242659;OTTHUMP00000242660;OTTHUMP00000242827;OTTHUMP00000242828;OTTHUMP00000242829;OTTHUMP00000243058;nascent-polypeptide-associated complex alpha poly

Recombinant Proteins

  • Mouse
  • Human
  • Chicken
  • Zebrafish
  • Mammalian Cells
  • Human
  • E.coli
  • HEK293
  • Yeast
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi

    Involved Pathway

    NACA involved in several pathways and played different roles in them. We selected most pathways NACA participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NACA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    NACA has several biochemical functions, for example, DNA binding,protein binding,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NACA itself. We selected most functions NACA had, and list some proteins which have the same functions with NACA. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding SS18L1,HDGFRP2,PROX2,SMARCA5,ISL2B,C3orf37,STAT5B,EXO1,MEIS1B,ZFP37
    protein binding ANXA4,PSMD4,PLIN5,MBD4,CCT6A,INTS3,GPI1,SNX15,GFI1,MYL7
    transcription coactivator activity NPAT,HCFC2,GABPA,KDM5A,KAT2B,NCOA1,HTATIP2,GTF2A1,TADA1,TRIP4

    Interacting Protein

    NACA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NACA here. Most of them are supplied by our site. Hope this information will be useful for your research of NACA.

    TXLNA;SRP54;BTT1;APLP1;MDM2;EGD1;gpmI;ilvD;RIF1;acoB;q81sn0_bacan;acnA;IGSF21;FUNDC2;CCDC90B;ZHX1;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;ere_dna

    Resources

    References

    • Tong, HF; Lin, DQ; et al. Caprylate as the albumin-selective modifier to improve IgG purification with hydrophobic charge-induction chromatography. JOURNAL OF CHROMATOGRAPHY A 1285:88-96(2013).
    • Jin, Y; Zhang, C; et al. Directing Dopaminergic Fiber Growth Along a Preformed Molecular Pathway From Embryonic Ventral Mesencephalon Transplants in the Rat Brain. JOURNAL OF NEUROSCIENCE RESEARCH 89:619-627(2011).

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