Recombinant Human NACA Protein, MYC/DDK-tagged

• Cat.No.: NACA-188H
• Product Overview: Recombinant human NACA protein, fused to MYC/DDK-tag at C-terminal, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016]
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 23.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: nascent polypeptide-associated complex alpha subunit [ Homo sapiens ]
• Official Symbol: NACA
• Synonyms: HSD48; MGC117224; NACA1
• Gene ID: 4666
• mRNA Refseq: NM_001113202.1
• Protein Refseq: NP_001106673.1
• MIM: 601234
• UniProt ID: Q13765