Recombinant Human Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric

• Cat.No.: MYL12A-5458H
• Product Overview: Recombinant Human MYL12A is produced in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: MYL12A is required for cytokinesis at the end of celldivision, when a contractile ring near the plasmalemma divides the cytoplasmof the daughter cells. They are involved in cytoplasmic streaming movementsin tissues, and especially in activation of motile cells such as fibroblastsand macrophages. Activation of non-muscle myosin-II is achieved byphosphorylation of Ser33 in the motif KKRPQRATSN by a dedicated, Ca +2Calmodulin regulated light chain kinase (MLCK).
• Form: Sterile filteredliquid in 20 mM HEPES-KOH, pH 7.0 + 50 mM NaCl + 1 mM EDTA + 1 mM DTT.
• Concentration: 0.5 mg/mL
• storage: Stablefor 1 year in working aliquots at -20°C to -80°C. Avoid repeated freeze-thawcycles.
• OfficialSymbol: MYL12A
• Pathways: Focal adhesion; Focal adhesion;Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Tightjunction

Gene Information

• Gene Name: MYL12A myosin, light chain 12A,regulatory, non-sarcomeric [ Homo sapiens ]
• Synonyms: MYL12A; myosin, light chain12A, regulatory, non-sarcomeric; MLCB; MRCL3; MRLC3; MYL2B; myosin regulatorylight chain 12A; MLC-2B; myosin RLC; OTTHUMP00000162243; myosin regulatorylight chain 3; myosin regulatory light chain MRCL3; myosin regulatory lightchain MRLC3; myosin regulatory light chain 2, nonsarcomeric; myosin, lightpolypeptide, regulatory, non-sarcomeric (20kD); RLC
• Gene ID: 10627
• mRNA Refseq: NM_006471
• Protein Refseq: NP_006462
• UniProt ID: P19105
• Chromosome Location: 18p11.31
• Function: calcium ion binding; glutamatereceptor binding